C1.1.5—Induced-fit binding
Induced-fit binding means substrate interaction changes active-site shape, aligning catalytic groups and straining substrate bonds during enzyme action in cells.
- Syllabus
- First assessment 2025
- Objective
- C1.1.5
- Level
- HL
Exam analysis
Chance of appearing2%of analysed past papers
Latest appearanceMay 2014
Most common paperPaper2
Typical marks2–6
Common command terms
- Describe
- Outline
Recent exam appearances
May 2014Paper2 ["HL"] · TZ25(b)[ 6 ]C1.1.5—Induced-fit binding
May 2013Paper2 ["HL"] · TZ13(c)[ 2 ]C1.1.5—Induced-fit binding
Practice this objective
Coverage 2013–2014 · Updated 15 Jul 2026
Concept essentials
- Induced fit involves a shape change when substrate binds.
- The active site is not a perfect rigid match before binding.
- Conformational change can weaken substrate bonds and lower activation energy.
- Products leave and the enzyme can return to its active form.