Question 1
[Maximum number: 6]
Describe the lock and key model of enzyme activity and how the induced fit model extends it.
enzymes are (globular) proteins that are catalysts/lower activation energy of chemical reactions;
lock and key model:
explains specificity of enzyme-substrate;
the substrate (key) fits into/has complementary shape to the active site (lock) of the enzyme;
the active site can be changed by different chemicals/temperatures/pH so substrate cannot bind;
induced-fit model:
changes in the active site/conformational changes to allow substrate to bind;
the substrate induces the active site to change;
bonds weakened in the substrate (so easier to break);
explain reduction of activation energy/wider substrate specificity;
Award [3 max] if only one model addressed.