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C1.1.17 (HL)—Mechanism-based inhibition

Mechanism-based inhibitors become irreversible after enzyme-catalysed reaction begins, permanently blocking further catalytic activity at the active site during catalysis and treatment.

Syllabus
First assessment 2025
Objective
C1.1.17
Level
HL

Concept essentials

  • Mechanism-based inhibitors become activated during the enzyme reaction.
  • The resulting inhibition is irreversible.
  • The active site is permanently blocked or modified.
  • Penicillin inhibits bacterial transpeptidase and prevents cell-wall cross-linking.
ConceptIB Biology HL