Type II diabetes, a widespread and challenging health problem, is due to insulin resistance, which results in raised blood glucose. Alpha-glucosidase enzymes catalyse the hydrolysis of carbohydrates. Inhibition of the enzymes slows the absorption of glucose in the intestine and thus slows the rise in blood glucose. A study examined the inhibitory effect of five species of seaweed (Palmaria palmata, Saccharina latissima, Fucus vesiculosus, Ascophyllum nodosum and Alaria esculenta) on alpha-glucosidase. Dried seaweed extracts made with water or ethanol were added to maltose. The solutions were incubated, then analysed for glucose content.
The graph shows percent inhibition of alpha-glucosidase with different seaweed extracts compared with uninhibited enzyme activity (control).