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C2.1.11 (HL)—Tyrosine kinase receptors

Tyrosine kinase receptors activate intracellular kinase domains after ligand binding, often triggering phosphorylation cascades and changes in cell behaviour, linking signal detection to a specific target-cell response.

Syllabus
First assessment 2025
Objective
C2.1.11
Level
HL

Concept essentials

  • Tyrosine kinase receptors are transmembrane receptors with intracellular kinase activity.
  • Ligand binding activates phosphorylation on tyrosine residues.
  • Phosphorylation can recruit or activate downstream signalling proteins.
  • RTK pathways often regulate growth, differentiation and gene expression.
ConceptIB Biology HL