D1.3.9 (HL)—CRISPR-Cas9 gene editing
CRISPR-Cas9 uses guide RNA targeting and Cas9 cutting to alter DNA sequences by deletion, insertion, disruption or replacement in selected genes.
- Syllabus
- First assessment 2025
- Objective
- D1.3.9
- Level
- HL
Exam analysis
Chance of appearing1%of analysed past papers
Latest appearanceMay 2025
Most common paperPaper2
Typical marks3
Common command terms
- Explain
Recent exam appearances
May 2025Paper2 ["HL"] · TZ27(c)[ 3 ]D1.3.9 (HL)—CRISPR-Cas9 gene editing
Practice this objective
Coverage 2025–2025 · Updated 16 Jul 2026
Concept essentials
- Guide RNA directs Cas9 to a complementary DNA target.
- Cas9 cutting creates the opportunity for DNA sequence change.
- CRISPR-Cas9 can disrupt, delete, insert or replace DNA.
- Editing a disease gene can alter the protein produced from that gene.