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IB Biology HL D1.3.9 Hl Crispr Cas9 Gene Editing Questions

Analyse how guide-directed DNA replacement can correct dystrophin mutations and change the resulting protein sequence in IB Biology HL D1.3.9.

Syllabus
First assessment 2025
Course
Biology HL
Level
HL

Exam points

  • Use a guide RNA and target-sequence replacement to direct CRISPR-Cas9 editing to a selected DNA region.
  • Apply CRISPR-Cas9 correction to a point mutation or stop codon so the dystrophin coding sequence produces a corrected or longer protein.
  • Repair an insertion or deletion by adding or removing the corresponding DNA section in the dystrophin gene.

Learn this topic

Study D1.3.9 (HL)—CRISPR-Cas9 gene editing conceptsOpen the corresponding Concept lesson for explanations, examples and exam connections.

IB Biology HL D1.3.9 Hl Crispr Cas9 Gene Editing Questions question 1

[Maximum number: 3]

Duchenne muscular dystrophy (DMD) is a sex-linked genetic disorder caused by a recessive allele resulting from mutations in the X-linked dystrophin gene. This causes the degeneration of cardiac and skeletal muscle. These mutations can include deletions, insertions and base substitution mutations.

Explain ways in which CRISPR-Cas9 gene editing could be used to change the mutated dystrophin protein produced.

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