IB Biology HL 1.3.9 CRISPR-Cas9 gene editing Question Bank
Practise IB Biology HL 1.3.9 by applying crispr-cas9 gene editing concepts to exam-style questions.
- Syllabus
- First assessment 2025
- Course
- Biology HL
- Level
- HL
Exam points
- identify the relevant biological structure, process or evidence
- apply the correct biological mechanism to the question
- evaluate the result using data, adaptation or ecological reasoning
D1.3.9 (HL)—CRISPR-Cas9 gene editing question 1
[Maximum number: 3]
Duchenne muscular dystrophy (DMD) is a sex-linked genetic disorder caused by a recessive allele resulting from mutations in the X-linked dystrophin gene. This causes the degeneration of cardiac and skeletal muscle. These mutations can include deletions, insertions and base substitution mutations.
Explain ways in which CRISPR-Cas9 gene editing could be used to change the mutated dystrophin protein produced.
a. gene editing requires a method for finding a target sequence in the genome/DNA/gene and replacing it with the desired sequence;
b. (gene editing could) change codon/point mutation/substitution that encodes/codes for a different amino acid (causing change in protein/dystrophin);
c. change codon that introduced a stop codon (making shorter peptide/dystrophin);
d. introduce DNA section/bases if mutation is a deletion;
e. delete DNA section/bases if mutation is an insertion;
a. both parts needed.
3 max
All question bank results loaded