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D1.1.2—Semi-conservative replication

Semi-conservative replication explains how DNA is copied, checked, amplified or analysed through specific strand relationships, enzyme functions and molecular techniques.

Syllabus
First assessment 2025
Objective
D1.1.2
Level
HL

Exam analysis

Chance of appearing2%of analysed past papers
Latest appearanceMay 2024
Most common paperPaper1
Typical marks1–3

Common command terms

  • Explain
  • Outline
  • Distinguish
  • Identify
  • State

Scoring notes

Common mistake
Saying both parental strands stay together instead of one parental strand entering each daughter molecule.

Recent exam appearances

May 2024Paper2 ["HL"] · TZ17(a)[ 3 ]D1.1.2—Semi-conservative replication
May 2014Paper1 ["HL"] · TZ26[ 1 ]D1.1.2—Semi-conservative replication
Practice this objective

Coverage 2014–2024 · Updated 16 Jul 2026

Concept essentials

  • Semi-conservative replication depends on matching each strand, enzyme or laboratory step to its exact function.
  • Template strands and complementary base pairing give semi-conservative replication its copying accuracy.
  • Semi-conservative replication is clearer when amplification, separation and profiling are not confused.
  • Molecular evidence for semi-conservative replication must be interpreted from bands, isotopes, primers or enzyme roles.
ConceptIB Biology HL