C3.1 Integration of body systems

Integrated body systems coordinate neural, hormonal and plant responses through receptors, control centres and effectors, maintaining function across organisms and changing environmental conditions.

Syllabus
First assessment 2025
Topic
C3.1
Level
HL

Learning objectives

C3.1.1System integration• Integration lets interacting parts coordinate an overall biological function• Systems interact across molecular, cellular, organ, organism, and ecosystem levelsC3.1.2Hierarchy in multicellular organisms• Cells form tissues, organs, organ systems, and whole organisms• Emergent properties arise when subsystems interact, such as gut peristalsis and absorptionC3.1.3Integration of organs• Organs are integrated by nervous signals, hormones, and blood transport• Transport links nutrients, gases, wastes, hormones, and energy substrates between organsC3.1.4Brain as information integration organ• The brain integrates sensory input and coordinates complex responses• Cerebral hemispheres, cerebellum, hypothalamus, and medulla have distinct rolesC3.1.5Spinal cord• The spinal cord links brain and peripheral nervous system• It integrates unconscious processes such as reflex arcsC3.1.6Input through sensory neurons• Sensory neurons carry impulses from receptors to spinal cord and brain• Inputs may reach cerebral hemispheres for conscious perceptionC3.1.7Output through motor neurons• Motor neurons carry impulses from CNS to skeletal muscle effectors• Voluntary muscle contraction is coordinated through cerebral hemispheresC3.1.8Nerves as bundles• Nerves are bundles of sensory and motor nerve fibres in connective tissue• Mixed nerves carry impulses both to and from the CNSC3.1.9Pain reflex arcs• Pain reflexes are rapid involuntary withdrawal responses• Reflex arcs use receptors, sensory neurons, relay neurons, motor neurons, and skeletal muscleC3.1.10Cerebellum role• The cerebellum coordinates timing and force of skeletal muscle contractions• It maintains balance, posture, and smooth learned movementsC3.1.11Melatonin and sleep• The pineal gland secretes melatonin according to light-dark cycles• Melatonin modulates sleep timing as part of circadian rhythmsC3.1.12Epinephrine (adrenaline)• Adrenal glands secrete epinephrine during stress or danger• It increases heart rate, ventilation, and respiratory substrate availabilityC3.1.13Hypothalamus and pituitary control• The hypothalamus links nervous inputs to endocrine control• Pituitary hormones regulate glands including thyroid, gonads, adrenals, and mammary glandsC3.1.14Heart rate feedback control• Baroreceptors monitor blood pressure; chemoreceptors monitor CO₂, pH, and O₂• The medulla adjusts sinoatrial node activity by sympathetic and parasympathetic nervesC3.1.15Ventilation rate feedback control• Chemoreceptors detect CO₂-driven pH changes in blood and cerebrospinal fluid• The medulla alters diaphragm and intercostal muscle activity to change ventilation rateC3.1.16Peristalsis control• The CNS controls voluntary swallowing and egestion• The enteric nervous system coordinates involuntary peristalsis in gut smooth muscleC3.1.17(HL)—Tropic responses in seedlings• Tropisms are directional growth responses in seedlings• Experiments compare shoot or root growth under lateral light or gravity stimuliC3.1.18(HL)—Positive phototropism• Shoots show positive phototropism toward lateral light• Auxin redistribution causes greater elongation on the shaded sideC3.1.19(HL)—Phytohormones• Phytohormones are plant signalling chemicals controlling growth and development• Auxin, cytokinin, and ethylene coordinate responses to stimuli and internal stateC3.1.20(HL)—Auxin efflux carriers• PIN auxin efflux carriers actively move auxin between plant cells• Asymmetric carrier placement maintains auxin gradients during tropic responsesC3.1.21(HL)—Auxin promotes cell growth• Auxin activates proton pumping into the apoplast• Acidified cell walls loosen, allowing water uptake, elongation, and bendingC3.1.22(HL)—Auxin and cytokinin interactions• Auxin generally promotes root formation; cytokinin promotes shoot formation and division• Their ratio coordinates root-shoot growth and plant tissue culture outcomesC3.1.23(HL)—Ethylene and fruit ripening• Ethylene is a gaseous phytohormone that promotes fruit ripening• Ripening fruit releases more ethylene, creating positive feedback in nearby fruit

Integration Creates a Function No Part Performs Alone

Integration is the coordination of interacting parts so the whole biological system performs an overall function. An emergent property appears through those interactions and is not a property of any isolated part.

Genes and molecular, cellular and organ integration contribute to an organism that also interacts with its ecosystem.
If the claim describes… Classify it as…
what one component can do by itself a component property
what coordinated components achieve together an emergent property
information or material passing between components evidence of integration

A smooth-muscle cell can contract, but one cell cannot propel a meal through an intestine. Peristalsis emerges when many cells, tissues and neural signals coordinate waves of contraction.

The Body Hierarchy Builds New Capabilities

cells → tissues → organs → organ systems → organism

Each level contains interacting subsystems from the level below; moving upward adds organisation, not merely more material.

Epithelial and smooth-muscle cells form tissues, the tissues form the small intestine, organs form the digestive system and organ systems form an organism.
Level Contribution to the intestine
epithelial tissue forms a selective surface for secretion and absorption
smooth-muscle tissue contracts and relaxes repeatedly
nervous and connective tissues coordinate movement and hold working tissues together
whole organ combines movement, digestion, absorption and transport

The organ's function depends on different tissue types interacting. Calling an organ ‘a group of similar cells’ misses the transition from tissue to organ.

Organs Coordinate through Signals and Shared Transport

Integrating route What travels Characteristic job
nervous signalling action potentials along neurons; neurotransmitter across synapses rapid, precise control of particular effectors
hormonal signalling hormones in blood coordinated effects in target cells with matching receptors
blood transport gases, nutrients, substrates, hormones and wastes physically links organ inputs and outputs

During exercise, motor neurons stimulate skeletal muscle, epinephrine changes several target organs, and blood delivers O₂ and glucose while carrying CO₂ away. No route replaces the others.

Blood reaches many tissues, but a hormone changes only cells with the appropriate receptor. Nervous output is targeted mainly by the physical wiring of the pathway.

Blood Links the Outputs of One Organ to the Needs of Another

Material Important route Why the route matters
glucose and amino acids small intestine → hepatic portal vein → liver → body tissues liver processes and buffers nutrient supply before wider distribution
O₂ lungs → red blood cells → respiring tissues supports aerobic ATP production
CO₂ respiring tissues → blood → lungs removes a respiratory waste and helps restore pH
urea liver → blood → kidneys transfers nitrogenous waste to the organ that excretes it

Long-chain lipids are rebuilt into triglycerides and packaged with protein before entering lymph, then the blood near the heart. Their hydrophobicity changes the transport route.

Transport integrates organs because one organ's output becomes another organ's substrate, signal or waste load. The circulation is the connecting route; it does not itself perform digestion, respiration or excretion.

Different Brain Regions Integrate Different Kinds of Information

Region Main integration role
cerebral hemispheres conscious perception, memory, planning and voluntary motor commands
cerebellum compares intended movement with sensory feedback to refine timing, force, posture and balance
hypothalamus links nervous information and blood conditions to autonomic and endocrine control
medulla adjusts involuntary functions including heart rate and ventilation
External and sectional brain views identify the cerebral hemispheres, cerebral cortex, hypothalamus, pituitary gland and cerebellum.

The brain is an integration organ because it receives, compares, stores and redistributes information. A region's role is not an isolated behaviour; it contributes to coordinated networks.

The Spinal Cord Is Both a Relay and a Local Integrating Centre

Spinal-cord role Information route Outcome
relay sensory input ascends to the brain; motor commands descend to peripheral neurons links brain and body
local integration sensory neuron synapses through relay neuron(s) to a motor neuron rapid unconscious response can begin without waiting for the brain

A spinal reflex is integrated in the spinal cord, but sensory impulses can still travel to the brain. Rapid withdrawal and later conscious pain are therefore compatible, not alternative explanations.

Spinal circuits also contribute to involuntary processes such as urination, defecation and some sweating. ‘Unconscious’ means not under direct voluntary control; it does not mean unregulated.

A Voluntary Action Closes the Loop from Receptor to Muscle

receptor transduces a stimulus → sensory neuron carries impulses into the CNS → relay neurons in brain networks support conscious perception → an upper motor neuron carries a command downward → a lower motor neuron reaches skeletal muscle → neurotransmitter at the neuromuscular junction triggers muscle action potentials and contraction

Sensory input from a receptor travels to the spinal cord and cerebral cortex, while upper and lower motor neurons carry output to a skeletal muscle.
Fibre Direction relative to CNS Function
sensory (afferent) receptor → CNS delivers information for integration
motor (efferent) CNS → skeletal muscle delivers the coordinated response

The cerebral hemispheres coordinate voluntary action, but they do not contract the muscle directly. The final output is carried by motor neurons to the neuromuscular junction.

A Mixed Nerve Bundles Many Fibres in Protective Layers

Structure What it encloses
endoneurium one nerve fibre
perineurium one fascicle, or bundle of fibres
epineurium several fascicles plus blood vessels, forming the whole nerve
A peripheral nerve cutaway shows many axons grouped into fascicles, surrounded by endoneurium, perineurium and epineurium.

A neuron is one cell. A nerve fibre is a neuron's long conducting process, usually an axon. A nerve is a connective-tissue package containing many fibres.

A mixed nerve can carry sensory impulses toward the CNS and motor impulses away from it at the same time because those signals travel in different fibres.

Withdrawal Begins before Conscious Pain Is Interpreted

  1. A damaging stimulus activates a pain receptor in the skin.
  2. A sensory neuron carries impulses into the spinal cord.
  3. A relay neuron transfers the signal to a motor neuron.
  4. The motor neuron stimulates a flexor skeletal muscle.
  5. The muscle contracts and withdraws the limb.
A pain receptor in skin sends an impulse through a sensory neuron to a spinal relay neuron and motor neuron, contracting a flexor muscle to withdraw the hand while information also travels to the brain.
Route Earliest outcome
spinal reflex arc rapid involuntary withdrawal
ascending pathways to brain conscious pain, awareness and memory
descending input from brain may modify the response after integration

The reflex trades deliberation for speed: a predictable protective response starts through a short spinal pathway while the brain receives and interprets the same event.

The Cerebellum Fine-Tunes Movement; It Does Not Initiate It

intended movement from cerebral cortex + sensory feedback about position and balance → cerebellum compares intention with performance → timing and force of motor output are adjusted → movement becomes smooth and posture remains stable

The cerebral cortex supplies an intended motor command, sensory receptors return information about the movement, and the cerebellum adjusts output so the movement becomes smooth.
Cerebellar contribution Example
timing activates muscles in the correct sequence
force prevents contraction from overshooting or undershooting
balance and posture uses receptor input to correct body position
learned precision refines writing, speech and practiced hand movements

The cerebellum coordinates and corrects skeletal-muscle contraction. Voluntary movement is initiated elsewhere, particularly in the cerebral cortex.

Melatonin Aligns Sleep Timing with the Light–Dark Cycle

A circadian rhythm is an approximately 24-hour pattern in physiology or behaviour. The pineal gland secretes melatonin as a hormonal timing signal within this clock system.

Environmental state Melatonin secretion Likely effect
darkness, including longer nights rises supports sleepiness and night-time timing
light falls supports preparation for wakefulness
abruptly shifted light–dark cycle internal rhythm and local time are misaligned jet lag persists while the clock resets

Melatonin modulates the timing of sleep; it is not a sedative switch that alone causes every transition into sleep. Light resets a continuing biological rhythm rather than producing an immediate, complete change.

Epinephrine Coordinates Organs for Immediate High Demand

During danger or stress, the adrenal medulla releases epinephrine into the blood. One hormone then coordinates target organs for vigorous activity.

Target response Immediate change Contribution to intense muscle contraction
heart heart rate and cardiac output increase delivers O₂ and glucose more rapidly
ventilation system breathing rate and depth increase increases gas exchange
liver glycogen is broken down and glucose enters blood raises available respiratory substrate
skeletal muscle and other responsive tissues metabolic pathways are shifted toward rapid ATP demand supports forceful activity

The important outcome is matched supply and demand: circulation, ventilation and fuel mobilisation rise together, allowing a higher rate of aerobic respiration and ATP production.

Epinephrine is an amino-acid-derived catecholamine, not a peptide hormone. It acts only in cells with appropriate adrenergic receptors.

The Hypothalamus Uses Two Routes to Control Pituitary Output

Pituitary part Hypothalamic route What the pituitary does
anterior releasing or inhibiting hormones travel through portal blood vessels endocrine cells synthesize and release pituitary hormones
posterior axons of hypothalamic neurosecretory cells end in the gland stores and releases ADH and oxytocin made in the hypothalamus
Hypothalamic neurosecretory cells regulate the anterior pituitary through a portal capillary system and send axons directly to the posterior pituitary.

Anterior-pituitary hormones regulate processes including growth, reproduction and homeostasis and can control endocrine glands such as the thyroid, gonads and adrenal cortex.

Calling the pituitary the ‘master gland’ is incomplete: the hypothalamus largely controls its activity, linking neural and endocrine information.

Heart-Rate Control Starts by Identifying the Disturbance

Receptor Variable detected Important locations What a change implies
baroreceptor stretch caused by blood pressure carotid sinus, aortic arch, right atrium pressure/venous return has changed
chemoreceptor mainly CO₂-linked pH; also O₂ carotid bodies, aortic bodies and brain/medulla gas exchange or metabolic demand has changed
  • High arterial pressure increases baroreceptor signalling and calls for a slower heart rate.
  • Low pressure calls for a faster, stronger response.
  • High CO₂ or low pH calls for increased blood flow so CO₂ reaches the lungs faster.

Sensory impulses converge on the cardiovascular centre in the medulla. The medulla integrates the evidence; receptors detect change but do not directly set the SA node.

Antagonistic Nerves Correct SA-Node Firing

Integrated condition Medulla increases output through… Transmitter at SA node SA-node effect
low pressure, high CO₂ or low pH sympathetic cardiac nerves norepinephrine firing rate rises; heart rate increases
high pressure or low CO₂ demand parasympathetic vagus nerve acetylcholine firing rate falls; heart rate decreases

disturbance → receptor firing changes → medulla integrates input → sympathetic or parasympathetic output changes → SA-node rate changes → blood pressure and gas transport move toward the required range

The SA node initiates each heartbeat within cardiac muscle. Autonomic nerves adjust its firing rate; they do not supply every impulse that causes the heart to contract.

Circulating epinephrine can also increase SA-node rate, so nervous and endocrine signals may reinforce one another during stress.

CO₂-Driven pH Feedback Adjusts Ventilation

  1. Cellular respiration raises blood CO₂.
  2. CO₂ forms carbonic acid, increasing H⁺ and lowering pH.
  3. Central and peripheral chemoreceptors increase signalling to respiratory centres in the medulla.
  4. Motor output to the diaphragm and external intercostal muscles increases rate and depth of contraction.
  5. Ventilation removes CO₂ faster, so H⁺ falls and pH moves back toward its set range.
Chemoreceptors in the medulla, aortic bodies and carotid bodies signal the respiratory centre, which controls intercostal muscles and the diaphragm.
Observation Best interpretation
CO₂ rises and pH falls ventilation should increase
exercise stops and CO₂ falls ventilation can decrease gradually
O₂ falls strongly peripheral chemoreceptors add a weaker but important drive

The principal routine stimulus is CO₂-linked H⁺, not a direct measurement of how hard the muscles are working. Voluntary control can temporarily override the automatic rhythm but does not replace it.

The Gut Combines Voluntary Boundaries with Enteric Control

Part of the route Main control Status
start of swallowing CNS and somatic motor pathways voluntary initiation
most movement through gut enteric nervous system, modulated by autonomic/CNS input involuntary
defecation boundary spinal/CNS reflexes plus voluntary control of external sphincter mixed control

Peristalsis is a travelling wave of contraction and relaxation in circular and longitudinal smooth muscle that propels gut contents forward.

The enteric nervous system contains sensory neurons, relay neurons and motor neurons in the gut wall. Local stretch and chemical information can therefore coordinate adjacent regions without a separate conscious command for every contraction.

Enteric is not a synonym for all autonomic control. The enteric nervous system specifically serves the gastrointestinal tract and is one specialised part of involuntary regulation.

SL Summary: Build a Coordinated Response from Routes and Feedback

System architecture: specialised cells form tissues and organs; nervous signals, hormones and circulating materials cross the boundaries between them; coordinated interaction creates emergent functions.

Control route: disturbance or stimulus → receptor evidence → integration centre → targeted motor or endocrine output → effector response → changed internal condition.

Observation Most useful place to inspect
touch is detected but no voluntary movement follows CNS integration, descending motor route or neuromuscular junction
pressure rises but heart rate does not fall baroreceptors, medulla, vagus nerve or SA node
CO₂ rises but breathing remains unchanged chemoreceptors, respiratory centre, phrenic/intercostal output
gut smooth muscle is intact but waves are uncoordinated enteric sensory, relay and motor circuits
Stabilising loop Coordinated response without a fixed set point
heart-rate and ventilation feedback oppose a disturbance epinephrine temporarily raises several outputs together for anticipated demand

A Tropism Experiment Must Measure Directional Growth

HL only

A tropism is a growth response whose direction is determined by the direction of a stimulus. A shoot curving toward lateral light shows positive phototropism; curvature itself is evidence of unequal growth.

Experimental decision Strong choice Why it matters
independent variable direction of light; compare lateral light with uniform light/dark control isolates stimulus direction
quantitative response angle of curvature or change in tip position over time measures magnitude and direction
qualitative response labelled drawings or images of seedling orientation records form and unexpected effects
controls species/age, water, temperature, distance and duration reduces alternative explanations
reliability replicate seedlings and report spread exposes biological variation and anomalies

Precision concerns agreement among repeated measurements; accuracy concerns closeness to the true value. Repeats can reveal spread, but they do not repair a systematically biased angle measurement.

The response must be growth. A rapid reversible movement is not a tropism even if it is directed by a stimulus.

Classic Shoot Experiments Locate Detection and a Mobile Signal

HL only
Manipulation under lateral light Result Supported inference
intact tip or transparent cap shoot bends toward light the normal response remains possible
opaque cap over tip no bending light detection requires the tip
tip removed no bending the tip supplies a coordinating influence
removed tip replaced on permeable agar bending restored a diffusible chemical signal can cross agar
impermeable block between tip and shoot no bending direct continuity or diffusion through a permeable route is required
agar block placed to one side in even light unequal growth and bending unequal signal distribution is sufficient to cause curvature

Together, the results support this model: the tip detects directional light and controls growth below it through a mobile chemical signal.

No single experiment proves the whole mechanism. The conclusion comes from controls and converging manipulations; the experiments locate detection and transmission before auxin chemistry is added.

Unequal Auxin Makes the Shaded Side Elongate More

HL only

lateral light is detected at the shoot tip → auxin becomes more concentrated on the shaded side → auxin moves to the elongation zone below the tip → shaded-side cells elongate more → unequal length curves the shoot toward the light

The shaded side becomes the longer outside of the curve, so the tip bends toward the illuminated side. Auxin does not pull the shoot toward light; it changes relative growth rates.

Uniform light produces equal shoot growth, while lateral light produces more growth substance on the shaded side so those cells elongate faster and the shoot bends toward light.
Light condition Auxin/growth across shoot Shape
light distributed equally approximately equal elongation on both sides grows straight
lateral light more auxin-driven elongation on shaded side curves toward light

Phytohormone Effects Depend on Place, Dose and Developmental State

HL only

Phytohormones are low-concentration plant signalling chemicals that coordinate growth, development and responses to stimuli. They are produced in several tissues rather than in one system of discrete endocrine glands.

Signal Selected coordinating roles Important context
auxin cell elongation, apical dominance, root formation and tropic growth high and low concentrations can have different effects; tissue matters
cytokinin cell division and shoot/lateral-bud development outcome depends strongly on interaction with auxin
ethylene fruit ripening and developmental responses gaseous signal can affect neighbouring tissues and fruit

Phytohormones may diffuse cell to cell or travel in vascular tissue. The same hormone can reinforce or oppose another signal, so its name alone does not predict the response.

A phytohormone is a regulator, not a nutrient or a source of energy. The response depends on receptors, tissue competence, concentration and developmental stage.

PIN Placement Gives Auxin Transport a Direction

HL only
  1. Auxin enters a cell from the apoplast.
  2. PIN efflux carriers export auxin at a particular side of the plasma membrane.
  3. ATP-dependent transport processes maintain the conditions needed for net export.
  4. When neighbouring cells place PIN carriers on corresponding sides, repeated export creates polar transport across the tissue.

A concentration gradient is maintained because carrier location is asymmetric. More carrier protein without coordinated placement would not by itself specify a tissue-level direction.

Change Predicted consequence
PIN carriers become evenly distributed directed auxin flow weakens
PIN-mediated efflux is inhibited auxin accumulates upstream and the downstream gradient changes
carriers are repositioned to another face net auxin movement changes direction

Auxin Turns Proton Pumping into Cell Elongation

HL only

auxin activates plasma-membrane H⁺ pumps → H⁺ accumulates in the apoplast → lower wall pH activates expansins → cellulose–hemicellulose interactions loosen → wall resistance to stretching falls → ion uptake and water entry maintain turgor → the yielding wall extends and the cell elongates

Auxin activates proton pumps, the apoplast acidifies, expansins loosen cellulose-hemicellulose interactions, ions and water enter, and the plant cell elongates.
Necessary contribution What it supplies
proton pumping acidic wall conditions
expansins and loosened cross-links wall extensibility
water entry and turgor force that stretches the loosened wall

Auxin does not enlarge a cell by adding wall material alone. It changes wall mechanics so existing turgor can produce elongation; sustained growth later requires new wall components.

Auxin–Cytokinin Balance Coordinates Root and Shoot Development

HL only

Shoot tips are important auxin sources and root tips are important cytokinin sources. Transport between these regions lets each growing organ influence the development of the other.

Relative signal balance in responsive tissue Typical developmental outcome
auxin high relative to cytokinin root formation is favoured
cytokinin high relative to auxin shoot formation is favoured
intermediate balance cell division/callus growth may be maintained

The ratio is a model of interaction, not a universal switch. Species, tissue identity, hormone concentration and developmental stage all affect the outcome.

Auxin and cytokinin can influence one another's production, transport and signalling. Their combined pattern coordinates allocation between roots and shoots more effectively than either signal acting independently.

Ethylene Makes Fruit Ripening Self-Amplifying

HL only

fruit begins to ripen → ethylene production rises → gaseous ethylene diffuses within and between fruit → ethylene stimulates more ripening → ripening tissues produce still more ethylene

This is positive feedback because the response increases the original change. The loop drives rapid, synchronized ripening rather than restoring fruit to its unripe state.

A ripening fruit releases gaseous ethylene that reaches neighbouring fruit and promotes their ripening.
Storage action Mechanistic prediction
remove ethylene from air or ventilate slows propagation of the ripening signal
keep ripe fruit beside unripe fruit accelerates ripening of neighbours
block ethylene perception reduces the tissue response even if ethylene is present

HL Summary: Turn Direction into Coordinated Growth

HL only

From evidence to model: controlled seedling observations locate light detection at the tip and support a mobile signal; lateral light is then explained by unequal auxin distribution and unequal elongation below the tip.

From signal to growth: asymmetric PIN placement gives auxin transport direction; auxin activates proton pumps; acidic walls activate expansins; turgor stretches the loosened wall.

From one hormone to a plant system: auxin and cytokinin balance root–shoot development, while ethylene diffuses among tissues and fruit to amplify ripening.

Observation Most direct interpretation
opaque tip cap prevents bending directional light detection requires the tip
auxin accumulates but fails to move basally PIN location or efflux is disrupted
wall pH falls but cells do not elongate wall loosening, water entry or turgor is limited
one ripe fruit accelerates nearby fruit a diffusible ethylene positive-feedback loop is operating
Animal integration Plant integration
rapid neural routes, circulating hormones and stabilising feedback often change cell activity polar chemical transport and differential growth often produce slower, lasting changes in form
both use receptors, signals, transport routes, integration and coordinated effectors both create whole-system outcomes that isolated components cannot produce

System integration

3 marks

Using the diagram, explain the concept of emergent properties of biofilms.

Hierarchy in multicellular organisms

1 mark

Why do multicellular organisms have emergent properties?

Integration of organs

3 marks

Pancreatic secretions contain sodium hydrogen carbonate, making them basic.
Deduce the significance of the response by the pancreas to secretin.

Brain as information integration organ

6 marks

Explain two methods that scientists have used to determine the different functions of the brain.

Spinal cord

1 mark

The spinal cord is involved in the coordination of involuntary actions such as the pain reflex.

Where are synapses between sensory neurons and interneurons found?

Input through sensory neurons

1 mark

Between which structures do sensory neurons carry nerve impulses?

Output through motor neurons

1 mark

What is the main role of nerves in human movement?

Nerves as bundles

1 mark

State the role of the vagus nerve.

Pain reflex arcs

4 marks

Draw a labelled diagram of a reflex arc for a pain withdrawal reflex.

Cerebellum role

2 marks

Describe the use of fMRI to identify the role of the cerebellum.

Melatonin and sleep

2 marks

Outline the role of melatonin in humans.

Epinephrine (adrenaline)

2 marks

Describe two ways in which epinephrine in the body facilitates intense muscle contraction. [2]
1.
2.

Hypothalamus and pituitary control

7 marks

Explain the roles of named hormones in the development and function of the sexual reproductive systems in males and females.

Heart rate feedback control

7 marks

Explain the control mechanism of the heart rate.

Ventilation rate feedback control

8 marks

Explain the causes of a decreased blood pH and its effects on the ventilation rate in humans.

Peristalsis control

3 marks

Outline how food is moved from the stomach to the large intestine.

Positive phototropism

HL only

5 marks

Outline how the hormone auxin controls phototropism in plant shoots.

Phytohormones exam focus

HL only

2 marks

State the name and site of production of two phytohormones that regulate the growth of seedlings.

Name of phytohormoneSite of production

Auxin efflux carriers

HL only

2 marks

Deduce the effect of NPA on auxin transport between L6 and the stem base.

Auxin promotes cell growth

HL only

2 marks

When a plant cell grows, the cell wall must expand. Explain the role of auxin in cell wall expansion.

Ethylene and fruit ripening

HL only

1 mark

Which chemical causes positive feedback to ensure rapid ripening of fruit?