IB Biology HL D1.2.18 Hl Polypeptide Modification Questions

IB Biology HL D1.2.18 covers how newly made polypeptides can be folded, cleaved or chemically modified, including preproinsulin processing to active insulin.

Exam points

Explain how cleavage of a precursor polypeptide can produce an active protein, using proinsulin processing to insulin as an example.
Describe activation of inactive protease precursors such as pepsinogen and trypsinogen by identifying the activating condition or enzyme.

[Maximum number: 1]

Insulin production involves processing pre-proinsulin to proinsulin and then processing proinsulin to insulin. In a model cell, the second processing step is blocked while synthesis of pre-proinsulin and its conversion to proinsulin continue normally.

Which product is most directly expected to accumulate?

Proinsulin

Pre-proinsulin

Mature insulin

Unspliced insulin pre-mRNA

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IB Biology HL D1.2.18 Hl Polypeptide Modification Questions question 1