IB Biology HL D2.2 Gene Expression Hl Only Questions

Practise IB Biology HL D2.2 by tracing gene expression, transcriptional control and epigenetic regulation from DNA activity to cell-specific proteins and phenotype.

Syllabus
First assessment 2025
Course
Biology HL
Level
HL

Exam points

  • Explain how transcription factors at promoters/enhancers activate or repress transcription and protein output.
  • Distinguish the genome from the proteome and relate a shared genome to tissue-specific protein sets.
  • Interpret gene-expression ratios to identify equal expression and the highest relative expression between groups.
  • Explain how DNA methylation and histone or nucleosome modification alter chromatin access and gene expression.
  • Interpret tumour-versus-normal methylation patterns and relate methylation to tumour-suppressor gene expression.
  • Link environmental conditions to methylation-mediated expression changes and interpret treatment data.
  • Explain and interpret post-fertilization methylation erasure and its role in early developmental gene expression.
  • Explain how monozygotic twins can develop different methylation patterns despite near-identical genomes.
  • Compare monozygotic/non-identical twin concordance data and assess genetic, environmental and causal limits.
  • Trace how lactose binding the repressor frees the promoter for transcription and lactase production.

Question 1

[Maximum number: 7]

The genome is the total of all the DNA in an organism, containing all the genetic information required for development and growth.

Explain how gene expression can be regulated during transcription to determine an organism's phenotype.

Question 2

[Maximum number: 1]

What is a consequence of nucleases binding to mRNA?

A

Transcription stops.

B

mRNA binds to ribosomes.

C

More mRNA is synthesized.

D

mRNA cannot be translated again.

Question 3

[Maximum number: 1]

What is the proteome of an individual?

A

The amino acids unique to an individual making up the proteins in cells

B

The way in which an individual's polypeptides are folded into a three-dimensional structure

C

The proteins synthesized as an expression of an individual's genes

D

All possible combinations of amino acids an individual contains

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