IB Biology HL D2.1 Cell and Nuclear Division Questions

Practise IB Biology HL D2.1 by identifying cell-division stages, explaining meiosis outcomes and interpreting chromosome evidence.

Syllabus
First assessment 2025
Course
Biology HL
Level
HL

Exam points

  • explain how mitosis generates new cells and maintains chromosome number in growth or asexual reproduction
  • compare animal cleavage furrows with plant cell plates and organelle distribution during cytokinesis
  • explain DNA replication in S phase and calculate chromatid number after replication
  • identify shared mitosis/meiosis chromosome events, including sister-chromatid separation
  • sequence and identify mitotic phases from chromosome, spindle, nuclear and micrograph evidence
  • calculate mitotic index from cell counts and interpret changes in meristems or inhibitor data
  • sequence G1, S, G2, mitosis and cytokinesis; relate interphase to growth, replication and organelle duplication
  • link changing cyclin levels and CDK activation to cell-cycle checkpoints, transitions and spindle progression
  • trace meiosis I/II from homologous- to sister-chromatid separation and identify haploid outcomes
  • diagnose meiotic non-disjunction from chromosome counts or karyotypes for aneuploidy
  • explain gamete variation through crossing over, independent assortment and fertilisation
  • link proto-oncogene activation or tumour-suppressor loss to checkpoint failure and tumour growth
  • identify metastasis when cancer cells form a secondary tumour in a distant organ

Question 1

[Maximum number: 1]

What describes nuclear division in stem cells?

A

Clonal selection

B

Mitosis

C

Cytokinesis

D

Meiosis

Question 2

[Maximum number: 8]

Eukaryotes are a diverse group of organisms, including animals and plants.

Compare and contrast the processes of mitosis and cytokinesis in animal and plant cells.

Question 3

[Maximum number: 4]

The genome is the total of all the DNA in an organism, containing all the genetic information required for development and growth.

Distinguish between cell division by mitosis and by meiosis in eukaryote cells.

Question 4

[Maximum number: 1]

The image shows a cell from the root tip of an onion (Allium cepa) ( 2 n=16 ) during late prophase of mitosis.

Figure for Question 4 — IB Biology HL

How many chromatids are present in the cell?

A

8

B

16

C

32

D

64

Question 5

[Maximum number: 1]

What process occurs in both mitosis and meiosis?

A

Formation of chiasmata

B

Reduction division

C

Separation of chromatids

D

Exchange of alleles between non-sister chromatids

Question 6

[Maximum number: 2]

Describe what happens to the membranes of an animal cell during mitosis.

Question 7

[Maximum number: 1]

The following shows a micrograph.

Figure for Question 7 — IB Biology HL

How many cells are in metaphase?

A

2

B

3

C

5

D

7

Question 8

[Maximum number: 2]

The micrograph shows a plant cell of Lilium grandiflorum during meiosis.

Figure for Question 8 — IB Biology HL

Identify, giving reasons, the stage of meiosis shown by this cell.

Question 9

[Maximum number: 1]

In a strain of soybeans, high oil content (H) in seeds is dominant to low oil content (h) and four seeds in a pod (F) is dominant to two seeds in a pod (f). A farmer crosses two soybean plants, both with high oil content and four seeds in a pod. The offspring have a phenotypic ratio of 9: 3: 3: 1.

The image shows the karyotype of a person who developed as a female.

Karyotype photograph with chromosomes arranged in numbered groups 1–22 and a separate unnumbered chromosome at the right.

Determine, with a reason, whether this karyotype shows that non-disjunction has occurred.

Question 10

[Maximum number: 2]

Hemophilia is a sex-linked disease that affected some members of royal families in Europe during the 19th and 20th centuries.

Figure for Question 10 — IB Biology HL

Question (a)

(a)

The diagram shows the structure of two chromosomes after the first division of meiosis, assuming that there was no crossing over or chiasmata formation.

Figure for Question (a) — IB Biology HL
[ 2 ]

Question (i)

(i)

Draw the same chromosomes to show their structure at the same stage of meiosis if there had been one chiasma between two gene loci.

[ 1 ]

Question (ii)

(ii)

State the stage of meiosis where chiasmata formation may occur.

[ 1 ]

Question 11

[Maximum number: 4]

Question (a)

(a)

The photomicrograph shows a section of onion (Allium cepa) root tip cells.

× 1000

× 1000

[ 2 ]

Question (i)

(i)

Describe how a mitotic index could be obtained from this image.

[ 2 ]

Question (b)

(b)

Cadmium is a heavy metal that can cause environmental problems. Cadmium ions are released from various human activities such as the release of sewage sludge, mining and industrial processes. Plants take up cadmium ions and they enter food chains.

A study was carried out to look at the effect of various concentrations of cadmium ions on the mitotic index of the apical meristem of root cells from 4-day-old wheat (Triticum aestivum) seedlings.

Figure for Question (b) — IB Biology HL
[ 2 ]

Question (i)

(i)

State the effect of cadmium ion concentration on the mitotic index of root cells from wheat seedlings.

[ 1 ]

Question (ii)

(ii)

Suggest the effect the change in mitotic index would have on the wheat plant.

[ 1 ]

Question 12

[Maximum number: 1]

In which stage of the cell cycle are chromosomes duplicated?

Figure for Question 12 — IB Biology HL
A

G1 phase

B

G2 phase

C

S phase

D

Mitosis

Question 13

[Maximum number: 4]

Multicellular organisms benefit from cell specialization and division of labour.

Outline the processes occurring during interphase in the cell cycle.

Question 14

[Maximum number: 4]

Explain how the cell cycle is controlled.

Question 15

[Maximum number: 4]

Many biological processes are cyclical. Examples of cycles can be found at the level of the cell, the organism and the ecosystem.

Explain how changes to the cell cycle can result in tumour formation.

Question 16

[Maximum number: 1]

Which processes occur during the development of secondary tumours?

I. Cytokinesis
II. Metastasis
III. Mitosis

A

I and II only

B

II and III only

C

I and III only

D

I, II and III

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