IB Biology HL 2.1.11 Sickle-cell mutation and haemoglobin evidence Question Bank

Practise IB Biology HL 2.1.11 by analysing sequence evidence for the haemoglobin mutation and its effects.

Exam points

Deduce a mutation from normal and sickle-cell beta-haemoglobin sequences.
Explain how altered haemoglobin affects oxygen transport and red-cell function.

[Maximum number: 8]

Explain the cause of sickle cell anemia and how this disease affects humans.

a. caused by a single nucleotide/base substitution mutation/GAG to GTG

b. «mutation of» a gene of $\beta$ -globin/a subunit of hemoglobin

c. mRNA copies the mutation of DNA and substitutes an amino acid in hemoglobin «subunit»

d. glutamic acid is substituted by valine

e. sickle cell anemia involves distorted hemoglobin protein/HbS

f. «distorted HbS causes» distortion/sickling/shape change of red blood cells

g. «distorted/sickled red blood cells» block capillaries/blood flow

h. HbS/sickled red blood cells cannot carry enough oxygen «for the body»/leads to fatigue

i. low oxygen concentration seriously affects structure of HbS

j. homozygous «HbS/HbS» state causes severe anemia/death at low oxygen concentrations

k. heterozygous state has less anemia/minor effects/less effect of structure of hemoglobin OR heterozygous state only affected at high altitude/extreme exercise/low levels of oxygen

I. «heterozygous state» provides protection against malaria parasite/selective advantage in malaria areas

OWTTE

8 max

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D1.2.11—Mutations changing protein structure question 1