Memory B- and T-cells remain after the primary response declines. On re-exposure, immune memory helps produce a faster, stronger secondary response. Review these ideas in IB Biology HL C3.2.10.
The black-legged tick (Ixodes scapularis) is an arthropod which sucks blood from humans and other mammals. It is encountered mainly in wooded and semi-wooded areas.
Some ticks can be infected by the bacterium Borrelia burgdorferi. When a tick bites a human, the bacterium is often introduced, causing Lyme disease. Lyme disease is a public health problem in North America and, if left untreated, can cause important neurological impairment. The diagram represents the two-year life cycle of a tick.
White-footed mice (Peromyscus leucopus) in eastern North America's wooded areas often host B. burgdorferi bacteria. To determine whether bacterial transmission from mice to tick nymphs could be prevented, mice were vaccinated with antigens from Lyme disease-causing B. burgdorferi. Scientists captured wild mice at two different sites in the woods once a month, over 4 months. Each time, they measured the levels of antibodies to B. burgdorferi present in the captured and re-captured mice, inoculated all of them, and released them into the woods. The control group was not vaccinated with B. burgdorferi antigen.
Suggest possible reasons for the observed pattern of presence of antibodies in vaccinated mice.
The summer after vaccination, the prevalence of B. burgdorferi infection in tick nymphs collected on mice from the two sites was measured.