IB Biology HL C2.2 Neural Signalling Questions

Practise IB Biology HL C2.2 with membrane-potential traces and synapse data covering action potentials, neurotransmitters, saltatory conduction, summation and drugs.

Syllabus
First assessment 2025
Course
Biology HL
Level
HL

Exam points

  • Label neuron structures and distinguish motor and sensory neuron arrangements and connections.
  • Define resting potential and explain how the ATP-driven sodium-potassium pump maintains 3 Na⁺-out/2 K⁺-in gradients and axon polarization.
  • Explain action-potential initiation through threshold and all-or-none response, voltage-gated Na⁺ influx/depolarization, delayed K⁺ efflux and repolarization or hyperpolarization.
  • Interpret action-potential traces and oscilloscope output using threshold, ion movement and channel timing, including membrane-potential change calculations.
  • Calculate and compare conduction speeds using axon-diameter and myelin data.
  • Explain how local Na⁺ currents depolarize the next axon region to threshold during propagation.
  • Identify nodes of Ranvier and myelin, then explain node-to-node saltatory conduction and speed.
  • Explain one-way synaptic transmission using acetylcholine receptor binding, breakdown and postsynaptic effects.
  • Explain how an arriving action potential opens Ca²⁺ channels, fuses vesicles and releases neurotransmitter.
  • Explain EPSP receptor binding and postsynaptic ion flow that causes depolarization.
  • Explain how exogenous chemicals alter synaptic transmission by mimicking, blocking or prolonging neurotransmitter effects.
  • Distinguish excitatory and inhibitory inputs and explain temporal/spatial summation reaching threshold.
  • Interpret fMRI scans to compare activation patterns and motor function after stroke.

Question 1

[Maximum number: 12]

Question (a)

(a)

Draw a labeled diagram to show the structure of a motor neuron.

[ 4 ]

Question (b)

(b)

Explain how nerve impulses pass from one neuron to another neuron.

[ 8 ]

Question 2

[Maximum number: 4]

Outline how neurons generate a resting potential.

Question 3

[Maximum number: 1]

Neurons transmit electrical impulses. Which statement describes part of this process?

A

K+\mathrm{K}^{+}ions are pumped out of the cell to depolarize the membrane.

B

Ion channels let K+\mathrm{K}^{+}diffuse into the cell to depolarize the membrane.

C

Na+\mathrm{Na}^{+}ions are pumped into the cell to repolarize the membrane.

D

Ion channels let Na+\mathrm{Na}^{+}diffuse into the cell to depolarize the membrane.

Question 4

[Maximum number: 4]

Draw a labeled diagram to show the structure of a motor neuron.

Question 5

[Maximum number: 2]

Earthworms (Lumbricus terrestris) have a nerve cord on the ventral (underside) side of their body. It contains three nerve fibres (axons), each with a very large diameter, which extend along the whole length of the nerve cord. There is one medial giant fibre (MGF) and two lateral giant fibres (LGFs). The diameter of the MGF is 1.4 times larger than the LGF.

Scientists developed a non-invasive method to record giant nerve fibre activity. The response from the MGF was measured by the electrical activity produced when touching the front segments of the earthworm while the LGF was measured when touching the back segments.

Figure for Question 5 — IB Biology HL
Figure for Question 5 — IB Biology HL

The table shows the mean conduction rates, standard deviation (SD) and number of individual measurements of MGF and LGF action potentials in each earthworm. At the end of the table, the mean and standard error (SE) for 9 of the earthworms are shown.

Table for Question 5 — IB Biology HL

Question (a)

(a)

Calculate the ratio of the mean conduction rate in the MGF to the mean conduction rate in the LGF.

[ 1 ]

Question (b)

(b)

Suggest one possible reason that the conduction rate in the MGF is much faster than in the LGF.

[ 1 ]

Question 6

[Maximum number: 1]

The diagram shows part of two neurons.

Figure for Question 6 — IB Biology HL

State the name of the structure shown.

Question 7

[Maximum number: 3]

The diagram shows part of two neurons.

Figure for Question 7 — IB Biology HL

X indicates the movement of a structure in the neuron. Explain what events trigger this movement and what happens next.

Question 8

[Maximum number: 2]

Cholinergic synapses use acetylcholine as their neurotransmitter. They are widespread in the body, passing on signals to muscle cells. These synapses are affected by neonicotinoid pesticides.

The diagrams, which are not drawn to scale, show the synapse between two neurons and a detail of the synaptic cleft.

Figure for Question 8 — IB Biology HL

Explain how acetylcholine initiates an action potential in a postsynaptic membrane.

Question 9

[Maximum number: 2]

Cholinergic synapses use acetylcholine as their neurotransmitter. They are widespread in the body, passing on signals to muscle cells. These synapses are affected by neonicotinoid pesticides.

The diagrams, which are not drawn to scale, show the synapse between two neurons and a detail of the synaptic cleft.

Figure for Question 9 — IB Biology HL

Outline how depolarization of the membrane of an axon occurs.

Question 10

[Maximum number: 4]

Multicellular organisms benefit from cell specialization and division of labour.

Describe what occurs in a neuron when an action potential is propagated along the axon.

Question 11

[Maximum number: 1]

Earthworms (Lumbricus terrestris) have a nerve cord on the ventral (underside) side of their body. It contains three nerve fibres (axons), each with a very large diameter, which extend along the whole length of the nerve cord. There is one medial giant fibre (MGF) and two lateral giant fibres (LGFs). The diameter of the MGF is 1.4 times larger than the LGF.

Scientists developed a non-invasive method to record giant nerve fibre activity. The response from the MGF was measured by the electrical activity produced when touching the front segments of the earthworm while the LGF was measured when touching the back segments.

Figure for Question 11 — IB Biology HL
Figure for Question 11 — IB Biology HL

The table shows the mean conduction rates, standard deviation (SD) and number of individual measurements of MGF and LGF action potentials in each earthworm. At the end of the table, the mean and standard error (SE) for 9 of the earthworms are shown.

Table for Question 11 — IB Biology HL

State the apparatus used to show the resting and action potentials.

Question 12

[Maximum number: 3]

Earthworms (Lumbricus terrestris) have a nerve cord on the ventral (underside) side of their body. It contains three nerve fibres (axons), each with a very large diameter, which extend along the whole length of the nerve cord. There is one medial giant fibre (MGF) and two lateral giant fibres (LGFs). The diameter of the MGF is 1.4 times larger than the LGF.

Scientists developed a non-invasive method to record giant nerve fibre activity. The response from the MGF was measured by the electrical activity produced when touching the front segments of the earthworm while the LGF was measured when touching the back segments.

Figure for Question 12 — IB Biology HL
Figure for Question 12 — IB Biology HL

The table shows the mean conduction rates, standard deviation (SD) and number of individual measurements of MGF and LGF action potentials in each earthworm. At the end of the table, the mean and standard error (SE) for 9 of the earthworms are shown.

Table for Question 12 — IB Biology HL

Explain saltatory conduction.

Question 13

[Maximum number: 1]

Cholinergic synapses use acetylcholine as their neurotransmitter. They are widespread in the body, passing on signals to muscle cells. These synapses are affected by neonicotinoid pesticides.

The diagrams, which are not drawn to scale, show the synapse between two neurons and a detail of the synaptic cleft.

Figure for Question 13 — IB Biology HL

On the diagrams, label:

On the diagrams, label with a letter P a location where a neonicotinoid pesticide could bind.

Question 14

[Maximum number: 3]

Describe how decision-making in the central nervous system (CNS) can result from the interaction between the activities of excitatory and inhibitory presynaptic neurons at synapses.

Question 15

[Maximum number: 1]

The following images identify brain activity associated with a specific function.

Figure for Question 15 — IB Biology HL
Figure for Question 15 — IB Biology HL

State the diagnostic tool used for functional analysis in the images.

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