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D2.2.5 (HL)—Genome, transcriptome, proteome

Genome, transcriptome and proteome distinguish inherited DNA information from expressed mRNA and dynamic protein output in cells over time and conditions.

Syllabus
First assessment 2025
Objective
D2.2.5
Level
HL

Exam analysis

Chance of appearing4%of analysed past papers
Latest appearanceMay 2023
Most common paperPaper1
Typical marks1

Common command terms

  • State
  • Calculate
  • Explain

Scoring notes

Common mistake
Assuming the genome and proteome are identical in all tissues.

Recent exam appearances

May 2023Paper1 ["HL"] · TZ27[ 1 ]D2.2.5 (HL)—Genome, transcriptome, proteome
November 2019Paper1 ["HL"] · TZ06[ 1 ]D2.2.5 (HL)—Genome, transcriptome, proteome
May 2019Paper1 ["HL"] · TZ27[ 1 ]D2.2.5 (HL)—Genome, transcriptome, proteome
November 2014Paper3 ["HL"] · TZ04(c)[ 1 ]D2.2.5 (HL)—Genome, transcriptome, proteome
November 2014Paper3 ["HL"] · TZ04(b)[ 1 ]D2.2.5 (HL)—Genome, transcriptome, proteome
Practice this objective

Coverage 2014–2023 · Updated 16 Jul 2026

Concept essentials

  • The genome is the complete genetic information.
  • The transcriptome is the set of RNA transcripts expressed at a time.
  • The proteome is the set of proteins produced at a time.
  • Different tissues can share a genome but have different proteomes.
ConceptIB Biology HL