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IB Biology HL D1.3.8 Hl Gene Knockout Questions

Analyse how disabling a gene reveals its function and how p53-knockout mice can test anti-cancer treatments in IB Biology HL D1.3.8.

Syllabus
First assessment 2025
Course
Biology HL
Level
HL

Exam points

  • Define gene knockout as making a specific gene inoperative or silencing its expression.
  • Infer the disabled gene's function by observing the phenotype or effect when its expression is absent.
  • Use a p53-knockout mouse to test how an anti-cancer drug affects tumours when the tumour-suppressor gene is absent.

Learn this topic

Study D1.3.8 (HL)—Gene knockout conceptsOpen the corresponding Concept lesson for explanations, examples and exam connections.

IB Biology HL D1.3.8 Hl Gene Knockout Questions question 1

[Maximum number: 1]

Knockout organisms are used as models in research. The p53 knockout mouse is named after p53, a gene which codes for a protein that normally suppresses the growth of cancerous tumours.

How could scientists use p53 knockout mice in cancer research?

A

To extract tumour suppressor protein from p53 knockout mice for cancer treatments

B

To obtain functional copies of the p53 gene to use in gene replacement therapy

C

To investigate the effect of new anti-cancer drugs on mouse tumours

D

To study the effect of mutations on the expression of the p53 gene

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