Trace how neurotransmitter binding changes postsynaptic ion flow, producing an EPSP that moves the membrane closer to action-potential threshold.
Cholinergic synapses use acetylcholine as their neurotransmitter. They are widespread in the body, passing on signals to muscle cells. These synapses are affected by neonicotinoid pesticides.
The diagrams, which are not drawn to scale, show the synapse between two neurons and a detail of the synaptic cleft.
Explain how acetylcholine initiates an action potential in a postsynaptic membrane.