Compare how temperature, oxygen, substrate, pH, organism size and metabolic demand affect respiration rate; interpret oxygen-uptake measurements from a respirometer in IB Biology HL C1.2.6.
Proteasomes are a group of proteins that destroy unwanted proteins in the cell, thereby maintaining cell health. However, chemical inhibitors can block the action of proteasomes, resulting in a build up of unwanted proteins with negative consequences for the cell.
Rat heart cells were incubated at different concentrations of a proteasome inhibitor in order to test its toxicity. The bar graph shows the percentage survival of these cells compared to untreated control cells.
Anticancer Therapeutic Agent Bortezomib', with permission from Elsevier.]
Describe the effect of the two treatments with proteasome inhibitor on mean oxygen consumption.