CAIE IGCSE Biology 11 Gas Exchange in Humans
Practise labelling airways, explaining alveolar exchange and interpreting ventilation, air-composition and exercise data.
- Syllabus
- 2026–2028
- Course
- Biology 0610
Practise labelling airways, explaining alveolar exchange and interpreting ventilation, air-composition and exercise data.
Fig. 6.1 shows part of the human gas exchange system.

Fig. 6.1
Table 6.1 shows the names of some parts of the human gas exchange system, their functions and the letters in Fig. 6.1 that identify the parts.
Complete Table 6.1.

Table 6.1
Complete correct answer:
Complete Table 6.1:
- traps particles before they enter the airway / mechanical barrier to pathogens: hairs in the nose; letter A.
- prevents collapse of the airway: cartilage; letter J / B.
- contracts to decrease the pressure in the thorax: external intercostal muscles; letter F.
- contracts to reduce the pressure / increase the volume in the thorax: diaphragm; letter C.
- protects the lungs from mechanical damage: rib(cage); letter E.
- contain cilia to move mucus out of the airway: trachea / bronchi / bronchiole; letter J / B / G.
- site of gas exchange: alveoli; letter H.
Marking guidance:
Award one mark for each correct row, maximum 7 marks.
Describe and explain how the alveoli are adapted for gas exchange.
any three from:
thin / one cell thick ;
large surface area ;
(which) reduces diffusion distance / AW ;
good blood supply ;
AVP ;
e.g. moist lining / presence of surfactant
Explain the differences in composition between inspired and expired air.
any three from:
less oxygen and more carbon dioxide in expired air (than inspired air) ;
(as) oxygen is required for aerobic respiration ; carbon dioxide is released by respiration ; water vapour increases (as it is released by respiration) ; AVP ;
Physical activity changes the concentration of carbon dioxide in the body.
State where this change is detected and how the body responds to the change.
detected:
either
(carbon dioxide is) in the blood
or
by the brain ;
response:
either
increases, rate / depth, of breathing
or
increases heart rate / AW ;
State the name of a solution that can be used to test for the presence of carbon dioxide gas.
limewater / hydrogencarbonate indicator (solution) / AVP ;
Substances move between blood and tissues at various sites in the circulatory system of mammals.
Oxygen is absorbed into the blood as it passes through the lungs.
State the structures in the lungs where oxygen passes into the blood from the air.
alveoli / alveolus ;
Complete Table 3.1 by writing in the percentages of carbon dioxide and oxygen in inspired air and in expired air.

Table 3.1
Complete correct answer:
Complete Table 3.1:
- carbon dioxide: 0.04% in inspired air (accept 0.03-0.08); 4% in expired air (accept 3-6).
- oxygen: 21% in inspired air (accept 19.5-23); 16% in expired air (accept 13.5-18).
Marking guidance:
Award 1 mark for 2 correct numbers and 2 marks for 4 correct numbers.
A scientist measured the number of dust particles in inspired air and in expired air.
They found fewer dust particles in expired air.
Suggest a reason for their observation.
any one from:
trapped in nose hairs ;
trapped in mucus ;
Fig. 3.1 is a diagram of alveoli and associated blood vessels.

Fig. 3.1
State the location and function of cartilage in the breathing system.
location
function
trachea ;
prevents airway collapse / keeps airway open / AW ;
function must match location
A bronchus / bronchi / bronchioles / sternum / ribs / larynx / nose
A allows, flexibility / movement
A protects vocal cords / prevents food from entering the lungs
A student measured the rate and depth of breathing of an athlete for 30 seconds at rest. The data are shown in Fig. 3.2.

Fig. 3.2
Using the information in Fig. 3.2, calculate the rate of breathing at rest. breaths per minute
The measurements were repeated while the athlete was running on a treadmill.
The data are shown in Fig. 3.3.

Fig. 3.3
12 / 13 (breaths per minute) ;
A 13.3 or 10.9
Using the information in Fig. 3.3, calculate the volume of air inspired in one breath from 25 seconds. dm3
2.5−2.6(dm3);
Explain the effect of exercise on the rate and depth of breathing shown in Fig. 3.2 and Fig. 3.3.
any four from:
1 more oxygen needed, for (aerobic) respiration / to release energy ;
2 (exercise uses) muscles (which need more energy) ;
3 ref. to muscle contraction ;
4 (exercise causes an) increased carbon dioxide concentration / lower pH , in the blood ;
5 (change in carbon dioxide / pH) detected by the brain ;
6 brain sends impulses to the, diaphragm / intercostal muscles (to stimulate, faster / larger, contractions) ;
7 to remove more carbon dioxide ;
8 ref. to adrenaline release (during exercise increasing breathing rate) ;