CAIE IGCSE Biology 13 Excretion in Humans
Review the organs and processes that remove metabolic waste, including lung excretion, urine formation and liver production of urea.
- Syllabus
- 2026–2028
- Course
- Biology 0610
Review the organs and processes that remove metabolic waste, including lung excretion, urine formation and liver production of urea.
The kidney is an organ in the excretory system.
Describe what is meant by the term excretion.
removal of waste products of metabolism ; and substances in excess (of requirements) ;
State the name of the substance excreted by the lungs.
(c) Fig. 4.1 shows a simplified diagram of a cross-section of a kidney.

Fig. 4.1
carbon dioxide ;
A water (vapour)
State the names of the parts labelled P, Q and R in Fig. 4.1.
P
Q
R
(d) Fig. 4.2 shows the structure of a kidney nephron.

Fig. 4.2
P - cortex ;
Q - ureter ;
R - medulla ;
Describe and explain the difference in the composition of the fluids in structures X, Y and Z in Fig. 4.2.
any six from:
1 X contains blood;
2 ref. to filtration (between X and Y );
3 proteins / blood cells / large molecules, too big to, be filtered / enter Y;
4 Y contains, glucose, water, urea and ions;
5 Z contains no glucose;
6 (all) glucose has been reabsorbed (into the blood);
7 Z contains excess, water/ions;
8 (some) water / ions, reabsorbed (into the blood);
9 Z contains high(er), concentration / AW, of urea;
10 Z contains urine;
The liver is also involved in excretion.
Describe two ways that amino acids are processed in the liver.
1
2
deamination / removal of nitrogen-containing part (to form urea) ; assimilation / conversion to or synthesis of proteins ;
AVP ;
The carbon dioxide produced during exercise is excreted. Urea is another substance that is excreted.
State the name of the organ that produces urea.
liver
State the name of the organ that excretes urea.
kidney
The diagram shows the human excretory system.
Which labelled structure is the urethra?

D
All living organisms excrete waste products.
Urea is a toxin that is excreted by the kidneys in humans.
Describe how and where in the body urea is formed.
any three from:
breakdown of (excess) amino acids ;
(by) deamination ;
removal of nitrogen containing part (of amino acid) ;
in the liver ;
Fig. 3.2 shows part of the human excretory system and associated blood vessels.
The arrows indicate the direction of blood flow.

not to scale
Draw a label line and the letter X on Fig. 3.2 to show the location of the cortex in one of the kidneys.
X marked on either kidney in the outer / edge region ;
Doctors wanted to investigate the effect of exercise on the excretion of salts.
They collected urine from people before and after running a long distance on a hot day.
The results of their investigation are shown in Table 3.2.

Table 3.2
Suggest why there is a difference in the volume of urine produced before running compared with after running.
Use the information in Table 3.2 in your answer.
any two from:
sweat more / lost more water (while running) ;
do not drink as much / reduced intake of water (while running) ;
ref. to homeostasis / negative feedback ;
AVP ;
Describe how the kidney tubules enable the excretion of salts.
any three from:
salts are in the blood / move from the blood into the tubule / AW ; ref. to glomerulus ;
(ultra)filters / allows through ;
pores / gaps, in capillary wall / narrow capillaries ;
small molecules are filtered / large are not filtered / AW ;
(some salt) reabsorption ;
ref. to active transport / diffusion ;
excess (salt) remains in the, urine / filtrate ;
AVP ;