IB Biology HL B2.1 Membranes and Membrane Transport Questions

Practise IB Biology HL B2.1 with membrane diagrams and data questions covering selective permeability, transport mechanisms, fluidity, vesicles and ion pumps.

Syllabus
First assessment 2025
Course
Biology HL
Level
HL

Exam points

  • Identify amphipathic phospholipid bilayers, explain head–tail orientation in water and relate the hydrophobic core to membrane barriers and compartment separation.
  • Define simple diffusion as passive net movement down a concentration gradient without ATP or transport proteins, including small non-polar molecules crossing the bilayer.
  • Distinguish integral, transmembrane and peripheral proteins and identify their channel, pump, receptor, enzyme, adhesion and recognition roles.
  • Define osmosis, predict water movement from solute or water-potential differences and explain how aquaporins increase water permeability.
  • Explain facilitated diffusion through selective channel proteins as passive movement down a gradient, using size, charge and polarity to explain selectivity.
  • Explain active transport by ATP-powered pumps, including sodium–potassium movement against gradients and the resulting ion gradients or resting potential.
  • Identify membrane glycoproteins and glycolipids with extracellular carbohydrate chains and relate the glycocalyx to recognition, adhesion and signalling.
  • Use the fluid mosaic model to locate hydrophilic heads, hydrophobic tails, embedded proteins and mobile membrane components, distinguishing it from the sandwich model.
  • Relate unsaturated and saturated fatty-acid composition and cholesterol to membrane packing, permeability, fluidity and temperature stability.
  • Explain how membrane fluidity permits vesicle budding, transport and fusion, and distinguish endocytosis from exocytosis.
  • Distinguish voltage-gated from ligand-gated ion channels and relate channel opening, membrane potential and potassium movement to nerve impulses.
  • Explain sodium-dependent glucose cotransport as secondary active transport driven by a sodium gradient maintained by basolateral pumps, including intestinal absorption.

Question 1

[Maximum number: 3]

Question (a)

(a)

Outline how the amphipathic properties of phospholipids play a role in membrane structure.

[ 2 ]

Question (b)

(b)

State the role of cholesterol in animal cell membranes.

[ 1 ]

Question 2

[Maximum number: 1]

Neural pathways in living brains can now be mapped by tracking the movement of water molecules inside axons. What keeps water molecules inside axons?

A

Plasma membrane

B

Hydrogen bonding

C

Pump proteins

D

Synapse

Question 3

[Maximum number: 1]

Which process results in the exchange of gases across the membrane of pneumocytes?

A

Active transport

B

Simple diffusion

C

Facilitated diffusion

D

Mass flow

Question 4

[Maximum number: 2]

Outline how the amphipathic properties of phospholipids play a role in membrane structure.

Question 5

[Maximum number: 4]

Oxygen is needed to complete aerobic cell respiration.

Outline four different functions of membrane proteins.

Question 6

[Maximum number: 3]

In the early 1990s, investigations involving egg cells from the African clawed frog (Xenopus laevis) led to the discovery of membrane channel proteins called aquaporins.

In one investigation, scientists injected 10 frog egg cells with a solution containing mRNA encoding for an aquaporin, and another 10 frog egg cells with distilled water (control cells). All the frog egg cells were then incubated in a hypotonic solution. The volume of the frog egg cells was then measured during a period of five minutes.

The graph shows the mean results of the investigation.

Relative frog egg-cell volume over five minutes. Filled squares show aquaporin-mRNA-injected eggs and open circles controls; the final filled-square point near three minutes is labelled egg cell bursts.

Question (a)

(a)

State the direction of net movement of water across the plasma membrane of all the frog egg cells between 0 and 3 minutes.

[ 1 ]

Question (b)

(b)

Explain the reasons for the different results obtained for the frog egg cells with aquaporin mRNA and the control frog egg cells.

[ 2 ]

Question 7

[Maximum number: 1]

The diagram shows protein channels involved in the passive movement of a substance into the cell across the cell membrane.

Figure for Question 7 — IB Biology HL

What describes this movement?

A

Energy of ATP is used to transport substances into the cell.

B

Substances can move from areas of low to areas of high concentration.

C

The proteins ensure that movement of substances is only in one direction.

D

Net movement occurs until the concentrations in and out of the cell are equal.

Question 8

[Maximum number: 3]

Calcium is absorbed from food in the human gut by both active and passive processes. Outline active transport, including the benefits of the process.

Question 9

[Maximum number: 1]

Cells use a variety of methods to move particles across membranes. What is a similarity between facilitated diffusion and active transport?

A

Both are carried out by proteins in the membrane.

B

Both move particles against the concentration gradient.

C

Both use ATP.

D

Both move non-polar ions across the membrane.

Question 10

[Maximum number: 1]

The diagram shows the cross section of a plasma membrane.

Figure for Question 10 — IB Biology HL

What is found in area X ?

A

Glycolipid

B

Glycoprotein

C

Polar amino acid

D

Non-polar amino acid

Question 11

[Maximum number: 4]

Draw a labelled diagram to show the fluid mosaic model of the plasma membrane.

Question 12

[Maximum number: 1]

Voltage-gated ion channels are proteins that are embedded in the phospholipid bilayer of plasma membranes. They conduct ions at high rates, regulated by the voltage across the membrane. The diagram shows a typical voltage-gated potassium ( K+\mathrm{K}^{+}) channel when it is closed and when it is open.

Figure for Question 12 — IB Biology HL

Outline the effect of fatty acids on the fluidity of membranes.

Question 13

[Maximum number: 1]

State the role of cholesterol in animal cell membranes.

Question 14

[Maximum number: 1]

Cholinergic synapses use acetylcholine as their neurotransmitter. They are widespread in the body, passing on signals to muscle cells. These synapses are affected by neonicotinoid pesticides.

The diagrams, which are not drawn to scale, show the synapse between two neurons and a detail of the synaptic cleft.

Figure for Question 14 — IB Biology HL

On the diagrams, label:

On the diagrams, label with a letter E a vesicle involved in exocytosis.

Question 15

[Maximum number: 4]

Voltage-gated ion channels are proteins that are embedded in the phospholipid bilayer of plasma membranes. They conduct ions at high rates, regulated by the voltage across the membrane. The diagram shows a typical voltage-gated potassium ( K+\mathrm{K}^{+}) channel when it is closed and when it is open.

Figure for Question 15 — IB Biology HL

Question (a)

(a)

Explain the action of the voltage-gated potassium channel during a nerve impulse.

[ 3 ]

Question (b)

(b)

State another type of gated ion channel.

[ 1 ]

Question 16

[Maximum number: 1]

Hypertension (blood pressure exceeding 140 mmHg ) affects millions of people worldwide. Many modern societies consume more sodium in the form of salt (NaCl) than is required for normal physiology. The effect of changing the levels of dietary sodium has been studied in various organisms.

Scientists recorded the blood pressure changes in chimpanzees (Pan troglodytes) fed a diet without added sodium (control) or a sodium supplemented diet (experimental) as follows
- 5 grams of salt per day from December 1991 until May 1992
- 10 grams of salt per day until June 1992
- 15 grams of salt per day until August 1993
after which no more salt was added to the diet until the experiment ended.

Figure for Question 16 — IB Biology HL

Suggest how sodium-potassium pumps in the membranes of nephron cells in the kidney could allow blood sodium concentrations to be reduced, if there is sufficient potassium in the diet.

Question 17

[Maximum number: 1]

What transport method is used in the reabsorption of glucose in the proximal convoluted tubule of the kidney?

A

Diffusion

B

Osmosis

C

Endocytosis

D

Active transport

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