Course review

C2.2 Neural signalling

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Learning objective

C2.2.1—Neurons

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• Neurons carry electrical impulses in the nervous system • Motor, sensory, and relay neurons differ in axon, dendrite, and cell body arrangement

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C2.2.2—Resting potential generation

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• Sodium-potassium pumps use ATP to move 3 Na⁺ out and 2 K⁺ in • Ion gradients make the resting axon polarized at about -70 mV

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C2.2.3—Nerve impulses as action potentials

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• A nerve impulse is a propagated action potential along a nerve fibre • Stimulus-triggered sodium influx reverses membrane polarity

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C2.2.4—Variation in impulse speed

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• Larger axon diameter lowers resistance and increases impulse speed • Myelin sheaths and nodes of Ranvier enable faster saltatory conduction

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C2.2.5—Synapses as junctions

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• Synapses connect neurons to neurons, muscles, or glands • Chemical synapses transmit one way across a narrow synaptic cleft

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C2.2.6—Neurotransmitter release

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• Action potentials open voltage-gated Ca²⁺ channels in presynaptic terminals • Ca²⁺ causes vesicle fusion and neurotransmitter exocytosis into the cleft

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C2.2.7—Excitatory postsynaptic potential

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• Neurotransmitters diffuse and bind receptors on the postsynaptic membrane • EPSPs depolarize the membrane and make threshold more likely

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C2.2.8 (HL)—Depolarization and repolarization

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• Threshold opens voltage-gated Na⁺ channels, causing rapid depolarization • Voltage-gated K⁺ channels then repolarize or briefly hyperpolarize the axon

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C2.2.9 (HL)—Action potential propagation

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• Local currents from Na⁺ diffusion depolarize the next axon region • Refractory regions behind the impulse help ensure one-way propagation

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C2.2.10 (HL)—Oscilloscope traces

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• Oscilloscope traces show resting potential, threshold, and action potential phases • Stimulus intensity is encoded by impulse frequency, not action potential size

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C2.2.11 (HL)—Saltatory conduction

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• Myelin insulates axons and ion exchange occurs mainly at nodes of Ranvier • Saltatory conduction jumps node to node and greatly increases speed

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C2.2.12 (HL)—Exogenous chemicals

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• Exogenous chemicals can mimic, block, or prolong neurotransmitter effects • Neonicotinoids bind insect acetylcholine receptors; cocaine blocks dopamine reuptake

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C2.2.13 (HL)—Inhibitory neurotransmitters

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• Inhibitory neurotransmitters open Cl⁻ entry or K⁺ exit channels • Hyperpolarization makes threshold harder to reach

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C2.2.14 (HL)—Summation

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• Postsynaptic neurons integrate EPSPs and IPSPs from many synapses • Temporal and spatial summation determine whether threshold is reached

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C2.2.15 (HL)—Pain perception

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• Pain uses free nerve endings with TRP ion channels in skin and other tissues • Heat, acid, capsaicin, or tissue damage can trigger impulses perceived as pain

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C2.2.16 (HL)—Consciousness

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• Consciousness emerges from coordinated activity across interacting brain regions • EEG, MRI, and fMRI provide evidence for neural correlates of conscious processing

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