• Neurons carry electrical impulses in the nervous system
• Motor, sensory, and relay neurons differ in axon, dendrite, and cell body arrangement
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2
Learning objective
C2.2.2—Resting potential generation
New
• Sodium-potassium pumps use ATP to move 3 Na⁺ out and 2 K⁺ in
• Ion gradients make the resting axon polarized at about -70 mV
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3
Learning objective
C2.2.3—Nerve impulses as action potentials
New
• A nerve impulse is a propagated action potential along a nerve fibre
• Stimulus-triggered sodium influx reverses membrane polarity
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4
Learning objective
C2.2.4—Variation in impulse speed
New
• Larger axon diameter lowers resistance and increases impulse speed
• Myelin sheaths and nodes of Ranvier enable faster saltatory conduction
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5
Learning objective
C2.2.5—Synapses as junctions
New
• Synapses connect neurons to neurons, muscles, or glands
• Chemical synapses transmit one way across a narrow synaptic cleft
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6
Learning objective
C2.2.6—Neurotransmitter release
New
• Action potentials open voltage-gated Ca²⁺ channels in presynaptic terminals
• Ca²⁺ causes vesicle fusion and neurotransmitter exocytosis into the cleft
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7
Learning objective
C2.2.7—Excitatory postsynaptic potential
New
• Neurotransmitters diffuse and bind receptors on the postsynaptic membrane
• EPSPs depolarize the membrane and make threshold more likely
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8
Learning objective
C2.2.8 (HL)—Depolarization and repolarization
New
• Threshold opens voltage-gated Na⁺ channels, causing rapid depolarization
• Voltage-gated K⁺ channels then repolarize or briefly hyperpolarize the axon
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9
Learning objective
C2.2.9 (HL)—Action potential propagation
New
• Local currents from Na⁺ diffusion depolarize the next axon region
• Refractory regions behind the impulse help ensure one-way propagation
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10
Learning objective
C2.2.10 (HL)—Oscilloscope traces
New
• Oscilloscope traces show resting potential, threshold, and action potential phases
• Stimulus intensity is encoded by impulse frequency, not action potential size
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11
Learning objective
C2.2.11 (HL)—Saltatory conduction
New
• Myelin insulates axons and ion exchange occurs mainly at nodes of Ranvier
• Saltatory conduction jumps node to node and greatly increases speed
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12
Learning objective
C2.2.12 (HL)—Exogenous chemicals
New
• Exogenous chemicals can mimic, block, or prolong neurotransmitter effects
• Neonicotinoids bind insect acetylcholine receptors; cocaine blocks dopamine reuptake
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13
Learning objective
C2.2.13 (HL)—Inhibitory neurotransmitters
New
• Inhibitory neurotransmitters open Cl⁻ entry or K⁺ exit channels
• Hyperpolarization makes threshold harder to reach
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14
Learning objective
C2.2.14 (HL)—Summation
New
• Postsynaptic neurons integrate EPSPs and IPSPs from many synapses
• Temporal and spatial summation determine whether threshold is reached
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15
Learning objective
C2.2.15 (HL)—Pain perception
New
• Pain uses free nerve endings with TRP ion channels in skin and other tissues
• Heat, acid, capsaicin, or tissue damage can trigger impulses perceived as pain
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16
Learning objective
C2.2.16 (HL)—Consciousness
New
• Consciousness emerges from coordinated activity across interacting brain regions
• EEG, MRI, and fMRI provide evidence for neural correlates of conscious processing
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