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D1.1.2—Semi-conservative replication

Semi-conservative replication explains how DNA is copied, checked, amplified or analysed through specific strand relationships, enzyme functions and molecular techniques.

Syllabus
First assessment 2025
Objective
D1.1.2
Level
SL

Exam analysis

Chance of appearing7%of analysed past papers
Latest appearanceMay 2025
Most common paperPaper1
Typical marks1–2

Common command terms

  • Explain
  • Outline
  • Distinguish
  • Identify
  • State

Scoring notes

Common mistake
Saying both parental strands stay together instead of one parental strand entering each daughter molecule.

Recent exam appearances

May 2025Paper1A ["SL"] · TZ26[ 1 ]D1.1.2—Semi-conservative replication
May 2024Paper2 ["SL"] · TZ24(b)(ii)[ 1 ]D1.1.2—Semi-conservative replication
November 2022Paper1 ["SL"] · TZ011[ 1 ]D1.1.2—Semi-conservative replication
May 2021Paper1 ["SL"] · TZ210[ 1 ]D1.1.2—Semi-conservative replication
November 2019Paper1 ["SL"] · TZ011[ 1 ]D1.1.2—Semi-conservative replication
Practice this objective

Coverage 2010–2025 · Updated 16 Jul 2026

Concept essentials

  • Semi-conservative replication depends on matching each strand, enzyme or laboratory step to its exact function.
  • Template strands and complementary base pairing give semi-conservative replication its copying accuracy.
  • Semi-conservative replication is clearer when amplification, separation and profiling are not confused.
  • Molecular evidence for semi-conservative replication must be interpreted from bands, isotopes, primers or enzyme roles.
ConceptIB Biology SL