A2.3.2 (HL)—Diversity of virus structure

Virus structures vary in genome chemistry and arrangement, capsid geometry, envelope presence, size, shape, and specialized components suited to different replication strategies.

Syllabus
First assessment 2025
Objective
A2.3.2
Level
HL

Exam analysis

Chance of appearing2%of analysed past papers
Latest appearanceNovember 2025
Most common paperPaper2
Typical marks2–7

Common command terms

  • Outline
  • State
  • Describe

Scoring notes

Common mistake
Claiming that a virus contains both DNA and RNA instead of one type of nucleic acid genome.

Recent exam appearances

November 2025Paper2 ["HL"] · TZ17(b)[ 7 ]A2.3.2 (HL)—Diversity of virus structure
May 2013Paper3 ["HL"] · TZ28(a)[ 2 ]A2.3.2 (HL)—Diversity of virus structure
Practice this objective

Coverage 2013–2025 · Updated 15 Jul 2026

Compare Genome, Capsid and Envelope Diversity

HL only

Viruses vary in genome type, capsid shape and whether they carry a host-derived membrane envelope.

Example Genome Outer structure Distinctive form
Bacteriophage lambda Double-stranded DNA Non-enveloped protein capsid with tail Complex head-tail particle that infects E. coli
Coronavirus Single-stranded RNA Enveloped with projecting spike proteins Roughly spherical enveloped particle
HIV Two copies of single-stranded RNA Enveloped Conical capsid inside the envelope

Across viruses, genetic material may be DNA or RNA and single- or double-stranded. Capsids can adopt different geometries, and envelopes are present in some lineages but absent in others.

An envelope can aid fusion with a host membrane but is more easily disrupted by detergents or drying than a protein capsid.

Shape alone does not determine host range or identify a species; receptor matching and replication compatibility also matter.

Diversity of virus structure

HL only

Assessment in practice

2 marks
How it is assessed

This objective is assessed through structured response, commonly using Outline / State / Describe.

Command terms

Outline / State / Describe

What earns marks

Build the answer around this relationship: Viral genomes may be DNA or RNA and may be single- or double-stranded.

Watch for

Claiming that a virus contains both DNA and RNA instead of one type of nucleic acid genome.

Representative question

Question 1

[Maximum number: 7]

Describe, with examples, the diversity of structure in viruses.

Build A Virus Answer

HL only

A strong HL virus answer usually combines two moves: define the boundary, then explain the mechanism or consequence. Viruses have DNA or RNA plus a capsid but lack the machinery for independent metabolism. Their diversity is described by genome, capsid, and envelope. Lambda phage lets you contrast lytic takeover with lysogenic integration. Origin questions require competing hypotheses and polyphyly. Evolution questions require mutation, recombination, short cycles, large populations, and examples such as influenza or HIV.

  • Definition: non-cellular obligate parasite with genome plus capsid, lacking cytoplasm/ribosomes/metabolic enzymes.
  • Structure: compare genome, capsid shape, and envelope status.
  • Replication: lytic = takeover and lysis; lysogenic = prophage integration and induction.
  • Origins: likely polyphyletic, with virus-first, escaped-gene, and regressive hypotheses.
  • Evolution: rapid variation explains vaccine updates and treatment resistance.

Concept essentials

  • Viral genomes may be DNA or RNA and may be single- or double-stranded.
  • Viral nucleic acid can be linear, circular, or segmented among multiple molecules.
  • Capsid shapes include helical, polyhedral, conical, and complex forms.
  • Only some viruses possess a host-derived lipid envelope.
  • Named examples reveal combinations of features that cannot be inferred from one trait alone.