Course review

C1.2 Cell respiration

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Learning objective

C1.2.1—ATP distributes energy

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• ATP is a small soluble nucleotide and universal energy currency • It links energy-yielding respiration to energy-requiring cellular processes

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Learning objective

C1.2.2—Life processes using ATP

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• ATP supplies active transport, anabolic synthesis, and movement • Examples include membrane pumps, macromolecule synthesis, and chromosome movement

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Learning objective

C1.2.3—ATP ↔ ADP interconversions

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• ATP hydrolysis to ADP and phosphate releases energy for coupled reactions • Respiration phosphorylates ADP to ATP; ATP is recycled rather than stored

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Learning objective

C1.2.4—Cell respiration system

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• Cell respiration is enzyme-controlled release of energy from organic compounds • Carbon compounds are oxidized stepwise so energy can be transferred to ATP

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Learning objective

C1.2.5—Anaerobic vs. aerobic respiration in humans

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• Aerobic respiration uses oxygen and mitochondria, producing CO₂, water, and high ATP • Anaerobic respiration in human cytoplasm produces lactate and low ATP

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Learning objective

C1.2.6—Variables affecting rate

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• Rate depends on metabolic demand, organism size, oxygen, substrate, temperature, and pH • Respirometers measure oxygen uptake while soda lime absorbs CO₂

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Learning objective

C1.2.7 (HL)—NAD as hydrogen carrier

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• NAD accepts hydrogen during oxidation/dehydrogenation reactions • Reduced NAD carries electrons and protons to the electron transport chain

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Learning objective

C1.2.8 (HL)—Glycolysis

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• Glycolysis converts glucose to two pyruvate molecules in the cytoplasm • It is a linear pathway with substrate-level ATP and reduced NAD net yield

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Learning objective

C1.2.9 (HL)—Pyruvate → lactate

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• Pyruvate accepts hydrogen from reduced NAD to form lactate • Regenerated NAD allows glycolysis to continue

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Learning objective

C1.2.10 (HL)—Anaerobic respiration in yeast

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• Yeast converts pyruvate to ethanol and CO₂ during alcoholic fermentation • Fermentation regenerates NAD for glycolysis and is used in baking and brewing

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Learning objective

C1.2.11 (HL)—Link reaction

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• Pyruvate is oxidized and decarboxylated in the mitochondrial matrix • Acetyl groups join coenzyme A to form acetyl-CoA for the Krebs cycle

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Learning objective

C1.2.12 (HL)—Krebs cycle

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• Acetyl-CoA combines with oxaloacetate to form citrate • The cycle regenerates oxaloacetate and yields CO₂, ATP, reduced NAD, and reduced FAD

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Learning objective

C1.2.13 (HL)—Electron transport chain

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• Reduced NAD and FAD donate electrons to carriers in the inner mitochondrial membrane • Electron transfers release energy while coenzymes are reoxidized

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Learning objective

C1.2.14 (HL)—Proton gradient generation

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• Electron transport energy pumps protons from matrix to intermembrane space • The inner membrane maintains a proton gradient and membrane potential

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Learning objective

C1.2.15 (HL)—Chemiosmosis

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• Protons flow through ATP synthase back into the matrix • ATP synthase couples proton flow to ADP phosphorylation by chemiosmosis

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Learning objective

C1.2.16 (HL)—Oxygen as terminal electron acceptor

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• Oxygen is the terminal electron acceptor at the end of the chain • Oxygen combines with electrons and protons to form metabolic water

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C1.2.17 (HL)—Lipids vs. carbohydrates as substrates

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• Lipids yield more ATP and metabolic water per gram because they are more reduced • Carbohydrates are easier to hydrolyse and enter glycolysis quickly

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