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D2.2 Gene expression [HL only]

Gene expression connects DNA, transcription regulation, epigenetic control, transcript stability, proteomes and environmental signals to phenotype in living cells and tissues.

Syllabus
First assessment 2025
Topic
D2.2
Level
—

What you’ll learn

11 learning objectives

Choose one objective for a focused lesson, or study the complete topic.

Exam analysis

An aggregate view of how the complete D2.2 Gene expression [HL only] appears across past papers.

Chance of appearing9%of analysed past papers
Latest appearanceNovember 2025
Most common paperPaper2

Most tested objectives

  1. D2.2.5 (HL)—Genome, transcriptome, proteome8 questions
  2. D2.2.2 (HL)—Regulation of transcription7 questions
  3. D2.2.6 (HL)—Epigenetic tags4 questions

Common question formats

  • Data analysis
  • Comparison
  • Definition or recall
  • Calculation
  • Process explanation

Exam question appearances

November 2025Paper2 ["SL"] · TZ31(g)[ 2 ]D2.2.5 (HL)—Genome, transcriptome, proteome
November 2025Paper2 ["SL"] · TZ31(e)[ 1 ]D2.2.5 (HL)—Genome, transcriptome, proteome
November 2025Paper2 ["SL"] · TZ31(d)[ 1 ]D2.2.5 (HL)—Genome, transcriptome, proteome
November 2025Paper1B ["HL"] · TZ11(c)[ 2 ]D2.2.6 (HL)—Epigenetic tags
May 2025Paper2 ["HL"] · TZ19(c)[ 7 ]D2.2.2 (HL)—Regulation of transcription
Practice this topic

6 original exam-style questions based on the patterns above.

Coverage 2011–2025 · Updated 16 Jul 2026

Study checklistD2.2 Gene expression [HL only]