CAIE A-Level Chemistry A2 34.3.2 Reactions of Amides Questions

Practise hydrolysing amides with aqueous alkali or acid and reducing their carbonyl group with LiAlH4 to form amines.

Exam points

describe alkaline or acidic hydrolysis of amides
describe reduction of the amide carbonyl group with LiAlH4 to form an amine
identify products and conditions for amide reactions

[Maximum number: 2]

Amino acids are molecules that contain $-\mathrm{NH}_{2}$ and -COOH functional groups.
Glycine, $\mathrm{H}_{2} \mathrm{NCH}_{2} \mathrm{COOH}$ , is the simplest stable amino acid.

Fig. 6.1 shows two syntheses starting with glycine.

Fig. 6.1

Draw the structure of the organic product U that forms when hippuric acid reacts with an excess of $\mathrm{LiAlH}_{4}$ in reaction 3 .

Figure for Answer to Question CAIE A-Level Chemistry A2 34.3.2 Reactions of Amides Questions question 1 — CAIE A-Level Chemistry A2

- carboxylic acid to primary alcohol COOH to $\mathrm{CH}_{2} \mathrm{OH}$

- amide to amine CONH to $\mathrm{CH}_{2} \mathrm{NH}$

- rest of the molecule is correct (carbons and benzene ring) mark as •

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CAIE A-Level Chemistry A2 34.3.2 Reactions of Amides Questions question 1