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CAIE A-Level Biology AS 6.2.7 Types of Mutations Questions

Use real CAIE Biology questions to compare original and mutated DNA sequences and classify each change as a substitution, insertion or deletion.

Syllabus
2028–2030
Course
Biology 9700
Level
AS

Exam points

  • Classify a substitution when one DNA base or base pair is replaced without changing sequence length.
  • Classify an insertion or deletion when DNA sequence length changes, using the altered sequence to name the mutation type.

CAIE A-Level Biology AS 6.2.7 Types of Mutations Questions question 1

[Maximum number: 1]

Row 1 and row 2 of Table 2.1 show the DNA base sequences of part of the normal CFTR allele and the same part of a mutated CFTR allele. The base sequences shown are for the DNA strands used in the synthesis of RNA. When Table 2.1 is completed, row 3 will show the base sequence of the RNA synthesised from the same part of the mutated CFTR allele.

Table 2.1

Table 2.1

The difference between the DNA base sequence in row 1 and the DNA base sequence in row 2 of Table 2.1 is caused by a single gene mutation.

State the name of this type of gene mutation.

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