Explain how gene transfer, expression and purification in genetically modified host cells produce recombinant human proteins in Cambridge A Level Biology questions, using…
Factor VIII can be made as a recombinant human protein.
Name the disease that is treated using recombinant human factor VIII.
haemophilia (A) ;
Before recombinant human factor VIII was available, this disease was treated with factor VIII from donated blood.
Give two advantages of using recombinant human factor VIII, instead of factor VIII from donated blood, to treat this disease.
any two from:
Marking guidance:
accept ora throughout
1 large / unlimited, supply ;
2 no risk of infection ;
3 no / fewer, ethical issues ;
4 less chance of, rejection / immune response / allergic response / side effects ;
5 cheap / quick, to produce ;
6 no need to wait for donor ;