Edexcel IGCSE Biology 3.34 Mutation
Practise defining mutation, comparing mutation rates in mitosis and meiosis, and using data to explain rates per division per cell.
- Syllabus
- First assessment 2019
- Course
- Biology 4BI1
Practise defining mutation, comparing mutation rates in mitosis and meiosis, and using data to explain rates per division per cell.
Mutation can cause changes in the enzymes produced during protein synthesis.
State what is meant by the term mutation.
An answer that makes reference to:
- (a rare random) change to DNA / change to gene / change to genetic material / eq
Scientists investigate the rate of spontaneous mutations in yeast.
They record the number of mutations per cell during mitosis and during meiosis.
They count the mutations in three different strains of yeast and repeat each count.
The mutation rates are counted per division per cell.

Suggest why the mutation is calculated per division per cell rather than just per cell.
An answer that makes reference to:
- two divisions in meiosis / one division in mitosis / mitosis and meiosis have different numbers of divisions / eq
Comment on the differences in rates of mutation for mitosis and meiosis in the different yeast strains.
An answer that makes reference to four of the following points:
- meiosis has higher mutation (in all strains) / mitosis has lower mutation / eq
- high(est) difference (between mitosis and meiosis) in 5207
- small(est) difference between (between mitosis and meiosis) in 5209
- low(est) mutation rates (for mitosis / meiosis) in 5209
- high(est) rate for mitosis in 5160
- high(est) rate for meiosis in 5207
- differences between repeats of each strain / eq