Name the epigenetic mark, state whether chromatin becomes more or less accessible and trace the effect through transcription, protein output and phenotype.
Proteins can control cell processes and determine cell structure.
DNA methylation can alter the activation of a gene.
Suggest the role of the enzyme DNA methyltransferase (DNMT) in the process of DNA methylation.
*(ii) Some cancers can be caused by the methylation of a tumour suppressor gene called RASSF1. Tumour suppressor genes can slow down cell division or cause cell death. Peperomin E is a drug that can cause the demethylation of the gene RASSF1. In an investigation different treatments were given to groups of 10 mice. These mice had identical lung cancer tumours at the start of the investigation. Graph A shows the changes in tumour volume for each group, over 21 days. Relative volume of tumour Thero Group A no treatment
Graph A Graph B shows the mean mass of tumours at 21 days.
Graph B Explain how treatment with these two drugs affects the activity of the RASSF1 gene and the changes in tumours. Use all of the information in part (c) and your own knowledge to support your answer.
