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Edexcel A-Level Biology AS 2.14 Dna Replication Errors and Mutations Questions

Distinguish substitution, insertion and deletion, trace codon and protein effects, and connect mutation or replication errors with cancer, inherited disorders and altered phenotypes.

Syllabus
First assessment 2019
Course
Biology YBI11
Level
AS

Exam points

  • Distinguish substitution, insertion and deletion mutations by their effects on a DNA base sequence.
  • Explain how codon changes can remove or alter amino acids and protein function.
  • Link DNA replication errors or mutation accumulation to cancer, inherited disorders and phenotype.

Edexcel A-Level Biology AS 2.14 Dna Replication Errors and Mutations Questions question 1

[Maximum number: 1]

Sickle cell disease is caused by a gene mutation affecting the β\beta-globin chain of haemoglobin.

The mutation occurs in the seventh triplet code of this gene.

This mutation results in the amino acid Glu being replaced with the amino acid Val.

The table shows the sequence of bases in the first part of the DNA in a person who does not have sickle cell disease. It also shows the corresponding sequence of amino acids in the β\beta-globin chain.

Table for Question Edexcel A-Level Biology AS 2.14 Dna Replication Errors and Mutations Questions question 1 — Edexcel A-Level Biology AS

Name the type of mutation that causes sickle cell disease.

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