CAIE A-Level Biology AS 8.2.4 Oxygen Dissociation Curve Questions
Interpret the oxygen dissociation curve and factors affecting haemoglobin affinity using evidence from each question and mark scheme.
- Syllabus
- 2028–2030
- Course
- Biology 9700
- Level
- AS
Interpret the oxygen dissociation curve and factors affecting haemoglobin affinity using evidence from each question and mark scheme.
During one cardiac cycle:
- blood enters the heart from the lungs and from the rest of the body
- blood leaves the heart to be transported to the lungs and to the rest of the body.
Fig. 3.2 shows the oxygen dissociation curve for adult haemoglobin in a person who does not have sickle cell anaemia.
Fig. 3.2
Compared to Fig. 3.2, the oxygen dissociation curve for adult haemoglobin in a person with sickle cell anaemia is shifted to the right.
The uptake of oxygen by haemoglobin in the lungs and the release of oxygen by haemoglobin in respiring tissues is different in a person with sickle cell anaemia compared with a person who does not have the disease.
With reference to Fig. 3.2, state and explain these differences.
uptake of oxygen
release of oxygen
any three from:
in terms of sickle cell:
1 low(er) affinity for oxygen / low(er) carrying ability of haemoglobin for oxygen / (more) difficult for oxygen to bind to haemoglobin / AW ;
uptake:
2 lower uptake of oxygen / lower saturation of haemoglobin (at same partial pressures) ;
release
3 oxygen is more easily released (at same partial pressures) ;
4 AVP ;
e.g. requires higher partial pressure of oxygen to reach same level of saturation ref. to structure of abnormal haemoglobin, e.g. sticky fibres reduced allosteric effect of haemoglobin molecule for uptake ref. to allosteric release of oxygen in respiring tissues ref. to sketch curve on graph and numerical comparison increase in, 2,3 -BPG / 2,3-DPG