CAIE A-Level Biology AS 11.1.3 Primary Immune Response Sequence Questions
Describe the primary immune response sequence after antigen exposure using evidence from each question and mark scheme.
- Syllabus
- 2028–2030
- Course
- Biology 9700
- Level
- AS
Describe the primary immune response sequence after antigen exposure using evidence from each question and mark scheme.
Nerium oleander is a xerophytic plant. A photomicrograph of a section through the leaf of N. oleander is shown in Fig. 3.1.
Fig. 3.1
Monoclonal antibody can be produced that is specific to cyFBPase. This antibody is used by investigators to check that the plants with the c y F B P mutation do not synthesise this enzyme.
In monoclonal antibody production, a small mammal is inoculated with cyFBPase and several weeks later cells are removed from the spleen. Some of these cells are required for the production process.
Describe the events occurring within the body of the small mammal that lead to the formation of the cells needed for monoclonal antibody production.
Four from:
1. primary immune response ;
2. cyFBPase / enzyme is antigen ;
3. formation of APC / antigen-presenting cell ;
4. antigen recognition / binding in context of B- or T-lymphocytes ;
5. detail, e.g. clonal selection / receptors complementary or specific to antigen or cyFBPase ;
6. divide by mitosis / clonal expansion ;
7. specific B-lymphocytes form plasma cells ;
8. plasma cells synthesise / secrete specific antibody / antibody to cyFBPase ;
9. T-helper / Th lymphocyte secretes cytokine / interleukin ;
10. stimulates humoral / B-lymphocyte response ;
Accept cell for lymphocyte throughout.
Accept antigens presented on surface of macrophages.
Accept immunoglobulin / antibody as receptors for B-lymphocytes.
Accept surface molecules as receptors for T-lymphocytes.