Course review

B1.1 Carbohydrates and lipids

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Learning objective

B1.1.1—Carbon atom properties

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• Carbon forms four strong covalent bonds with C, H, O, N, S, and P • Carbon skeletons form chains, branches, rings, and single or double bonds • Functional groups give carbon compounds distinctive chemical properties

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Learning objective

B1.1.2—Macromolecules by condensation

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• Condensation links monomers with covalent bonds and releases water • Polysaccharides, polypeptides, and nucleic acids are polymers made this way • Glycosidic, peptide, and phosphodiester bonds are key examples

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B1.1.3—Digestion by hydrolysis

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• Hydrolysis breaks covalent bonds in polymers using water • Water provides -H and -OH groups to form monomers • Amylases, proteases, and nucleases catalyse hydrolysis of major biomolecules

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Learning objective

B1.1.4—Form and function of monosaccharides

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• Pentoses such as ribose and hexoses such as glucose are monosaccharides • Glucose is soluble, transportable, chemically stable, and a direct respiratory substrate • Alpha- and beta-glucose differ at carbon 1 and form different polysaccharides

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B1.1.5—Polysaccharides as energy storage

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• Starch stores energy in plants as amylose and amylopectin • Glycogen stores energy in animals and fungi and is more highly branched • Insolubility, compactness, and easy hydrolysis make both effective glucose stores

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B1.1.6—Cellulose structure and function

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• Cellulose is made from beta-glucose joined by 1,4 glycosidic bonds • Alternating glucose orientation makes straight, unbranched chains • Hydrogen bonds form fibrils and fibres that strengthen plant cell walls

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Learning objective

B1.1.7—Glycoproteins in cell-cell recognition

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• Glycoproteins and glycolipids form the external glycocalyx of membranes • Cell-surface carbohydrates enable self/non-self recognition, adhesion, and signalling • ABO blood group antigens show how surface sugars affect immune compatibility

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B1.1.8—Hydrophobic properties of lipids

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• Lipids are hydrophobic, sparingly soluble in water, and soluble in non-polar solvents • Fats, oils, waxes, phospholipids, and steroids are lipid examples • Lipids are not true polymers because they are not built from repeating identical monomers

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B1.1.9—Formation of triglycerides and phospholipids

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• Condensation forms ester bonds between glycerol and fatty acids • Triglycerides contain glycerol plus three fatty acids • Phospholipids contain glycerol, two fatty acids, and an ionized phosphate group

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B1.1.10—Fatty acids

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• Saturated fatty acids have no carbon-carbon double bonds • Monounsaturated and polyunsaturated fatty acids have one or multiple double bonds • Double bonds create kinks, lower melting points, and affect membrane and storage properties

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B1.1.11—Triglycerides functions

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• Triglycerides in adipose tissue store concentrated long-term energy • Insoluble fat stores avoid osmotic effects and can provide insulation, protection, and buoyancy • Fat oxidation releases more energy and metabolic water than carbohydrate of the same mass

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B1.1.12—Phospholipid bilayers

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• Phospholipids are amphipathic with hydrophilic phosphate heads and hydrophobic tails • In water they form monolayers or bilayers with tails away from water • Bilayers are stable barriers and the basic structure of cell membranes

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B1.1.13—Non-polar steroids

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• Steroids are mostly non-polar lipids with four fused carbon rings • Non-polar steroids pass through the hydrophobic core of phospholipid bilayers • Oestradiol and testosterone are cholesterol-derived steroid hormone examples

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