AP Biology 4.6.A Cell-Cycle Checkpoints
Practise AP Biology 4.6.A questions by explaining how checkpoints, cyclin-CDK interactions and p53 regulate progression after DNA damage.
- Syllabus
- Effective Fall 2025
- Course
- AP Biology
Exam points
- explain how checkpoints and cyclin-CDK interactions regulate cell-cycle progression
- predict cell-cycle effects of DNA damage, checkpoint failure or checkpoint mutations
- connect p53 and CDK inhibitors to pausing, repair or entry into mitosis
4.6.A—Describe the role of checkpoints in regulating the cell cycle question 1
The p53 protein is a transcription factor that regulates a cell's progression through the cell cycle after DNA is damaged by ultraviolet (UV) radiation. The p53 pathway is shown in Figure 1.
Figure 1. The role of p53 in regulating cell cycle progression in response to DNA damage
Based on Figure 1, explain how p53 regulates the cell cycle in the presence of damaged DNA.
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