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AP Biology 4.6 A Describe the Role of Checkpoints in Regulating the Cell Cycle Questions

Practise AP Biology 4.6.A questions by explaining how checkpoints, cyclin-CDK interactions and p53 regulate progression after DNA damage.

Syllabus
Effective Fall 2025
Course
AP Biology

Exam points

  • explain how checkpoints and cyclin-CDK interactions regulate cell-cycle progression
  • predict cell-cycle effects of DNA damage, checkpoint failure or checkpoint mutations
  • connect p53 and CDK inhibitors to pausing, repair or entry into mitosis

AP Biology 4.6 A Describe the Role of Checkpoints in Regulating the Cell Cycle Questions question 1

[Maximum number: 1]

The p53 protein is a transcription factor that regulates a cell's progression through the cell cycle after DNA is damaged by ultraviolet (UV) radiation. The p53 pathway is shown in Figure 1.

Figure 1. The role of p53 in regulating cell cycle progression in response to DNA damage

Figure 1. The role of p53 in regulating cell cycle progression in response to DNA damage

Based on Figure 1, explain how p53 regulates the cell cycle in the presence of damaged DNA.

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