CAIE A-Level Biology AS 10.2.3 Antibiotic Resistance Questions
Explain how antibiotic resistance arises and spreads in bacterial populations using evidence from each question and mark scheme.
- Syllabus
- 2028–2030
- Course
- Biology 9700
- Level
- AS
Explain how antibiotic resistance arises and spreads in bacterial populations using evidence from each question and mark scheme.
Fig. 4.1 is a transmission electron micrograph of the bacterium that causes cholera, Vibrio cholerae.
The flagellum shown in Fig. 4.1 allows movement of the bacterium within the gut and may also function to help it to bind to an intestinal epithelial cell. The organism does not enter the cell but the toxin it releases can enter and cause damage. Large quantities of water, chloride ions and sodium ions are lost from the cell.
Fig. 4.1
People with symptoms of cholera have severe watery diarrhoea and as a result can become very dehydrated.
Some strains of V. cholerae are antibiotic resistant.
Explain why this means that medical practitioners prefer to treat cholera with a single dose of antibiotic, rather than a multiple dose of the same antibiotic.
Answer may be from the point of view of single dose or multiple dose.
The official markscheme answer is shown in the attached figure.
AVP examples:
- one dose may mean no / less antibiotic enters environment in faeces ;
- more effective treatment means bacteria are passed out for a shorter time, reducing risk of transmission of the pathogen ;
- multiple low dose antibiotics may increase mutagenesis ;
- if bacteria are resistant and not killed by antibiotic, single dose may have less effect on good gut bacteria ;
Allow AW.
Point 3 is for starting with susceptible bacteria and point 4 is for starting with resistant bacteria.
Penalise once if virus is used throughout.