Course review

C2.2 Neural signalling

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Learning objective

C2.2.1—Neurons

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• Neurons carry electrical impulses in the nervous system • Motor, sensory, and relay neurons differ in axon, dendrite, and cell body arrangement

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C2.2.2—Resting potential generation

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• Sodium-potassium pumps use ATP to move 3 Na⁺ out and 2 K⁺ in • Ion gradients make the resting axon polarized at about -70 mV

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C2.2.3—Nerve impulses as action potentials

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• A nerve impulse is a propagated action potential along a nerve fibre • Stimulus-triggered sodium influx reverses membrane polarity

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C2.2.4—Variation in impulse speed

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• Larger axon diameter lowers resistance and increases impulse speed • Myelin sheaths and nodes of Ranvier enable faster saltatory conduction

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C2.2.5—Synapses as junctions

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• Synapses connect neurons to neurons, muscles, or glands • Chemical synapses transmit one way across a narrow synaptic cleft

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C2.2.6—Neurotransmitter release

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• Action potentials open voltage-gated Ca²⁺ channels in presynaptic terminals • Ca²⁺ causes vesicle fusion and neurotransmitter exocytosis into the cleft

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C2.2.7—Excitatory postsynaptic potential

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• Neurotransmitters diffuse and bind receptors on the postsynaptic membrane • EPSPs depolarize the membrane and make threshold more likely

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