3.2.A—Explain how changes to the structure of an enzyme may affect its function

Explain how changes to the structure of an enzyme may affect its function.

• Change to the molecular structure of a component in an enzymatic system may result in a change to its function or efficiency.
  • i. Denaturation of proteins, such as enzymes, oc curs when the protein structure is disrupted by a change in temperature, pH, or chemical environment, eliminating the ability to catalyze reactions.
  • ii. Environmental temperatures and pH outside the optimal range f or a given enzyme will cause changes to its structure (by disrupting the hydrogen bonds), altering the efficiency with which it catalyzes reactions.
• In some cases, enzyme denaturation is reversible, allowing the enzyme to regain activity.