Edexcel IAL Chemistry Topic 19 Organic Nitrogen Compounds

Topic 19 questions ask you to move between structures, names and reactions of amines, amides, amino acids, diazonium salts, peptides and condensation polymers.

Exam points

Draw and classify amines, amides and amino acids from names or formulae.
Explain amine basicity, solubility and salt formation using nitrogen lone pairs.
Select reagents for amine preparation, diazonium chemistry, amide and peptide reactions.

Covered syllabus points

19.1—The nomenclature of amides, amines and amino acids 19.2—The reactions of primary aliphatic amines (using butylamine as an example) and aromatic amines (using phenylamine as 19.3—Amines are miscible with water as a result of hydrogen bonding, and the reasons for the difference in basicity between 19.4—Understand, in terms of reagents and general reaction conditions, the preparation of primary aliphatic amines: i 19.5—The preparation of aromatic amines by the reduction of aromatic nitro- compounds using tin and concentrated hydrochloric 19.6—The reaction of aromatic amines with nitrous acid to form benzenediazonium ions, followed by a coupling reaction with phenol 19.7—Amides can be prepared from acyl chlorides 19.8—Describe: i condensation polymerisation for the formation of polyamides such as nylon and proteins ii addition 19.9—Draw the structural formulae of the repeat units of the polymers in 19.8 19.10—Comment on the physical properties of polyamides and the solubility in water of the addition polymer poly(ethenol) in terms 19.11—Experiments to investigate the characteristic behaviour of amino acids limited to: i acidity and basicity and the formation 19.12—CORE PRACTICAL 15 Analysis of some inorganic and organic unknowns

[Maximum number: 2]

The amino acid serine has the structure shown.

Figure for Question Topic 19: Organic Nitrogen Compounds: Amines, Amides, Amino Acids and Proteins question 1 — Edexcel A-Level Chemistry A2

(a)

The IUPAC name for serine is

2-amino-2-carboxyethanol

2-amino-1-hydroxyethanoic acid

2-amino-1-hydroxypropanoic acid

2-amino-3-hydroxypropanoic acid

[ 1 ]

(b)

Which is the organic product of the reaction between serine and sodium hydroxide solution?
□ A

Figure for Question (b) — Edexcel A-Level Chemistry A2

□ B

□ C

□ D

[ 1 ]

[Maximum number: 3]

Two organic compounds, A and B, are colourless liquids.
Each compound contains only one functional group.

(a)

Two tests were carried out on B.

[ 3 ]

(i)

Complete the statements in the observation and inference columns.

Table for Question (i) — Edexcel A-Level Chemistry A2

[ 2 ]

(ii)

B has a molar mass of $59 \mathrm{~g} \mathrm{~mol}^{-1}$ .

Suggest a structure for B.

[ 1 ]

[Maximum number: 3]

The synthetic drugs of the 'Caine' family are used as local anaesthetics. Caine drugs prevent nerve activity by binding to sodium channel receptors in the lipid cell membranes of neurons.