• Carbon forms four strong covalent bonds with C, H, O, N, S, and P
• Carbon skeletons form chains, branches, rings, and single or double bonds
• Functional groups give carbon compounds distinctive chemical properties
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2
Learning objective
B1.1.2—Macromolecules by condensation
New
• Condensation links monomers with covalent bonds and releases water
• Polysaccharides, polypeptides, and nucleic acids are polymers made this way
• Glycosidic, peptide, and phosphodiester bonds are key examples
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3
Learning objective
B1.1.3—Digestion by hydrolysis
New
• Hydrolysis breaks covalent bonds in polymers using water
• Water provides -H and -OH groups to form monomers
• Amylases, proteases, and nucleases catalyse hydrolysis of major biomolecules
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4
Learning objective
B1.1.4—Form and function of monosaccharides
New
• Pentoses such as ribose and hexoses such as glucose are monosaccharides
• Glucose is soluble, transportable, chemically stable, and a direct respiratory substrate
• Alpha- and beta-glucose differ at carbon 1 and form different polysaccharides
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5
Learning objective
B1.1.5—Polysaccharides as energy storage
New
• Starch stores energy in plants as amylose and amylopectin
• Glycogen stores energy in animals and fungi and is more highly branched
• Insolubility, compactness, and easy hydrolysis make both effective glucose stores
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6
Learning objective
B1.1.6—Cellulose structure and function
New
• Cellulose is made from beta-glucose joined by 1,4 glycosidic bonds
• Alternating glucose orientation makes straight, unbranched chains
• Hydrogen bonds form fibrils and fibres that strengthen plant cell walls
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7
Learning objective
B1.1.7—Glycoproteins in cell-cell recognition
New
• Glycoproteins and glycolipids form the external glycocalyx of membranes
• Cell-surface carbohydrates enable self/non-self recognition, adhesion, and signalling
• ABO blood group antigens show how surface sugars affect immune compatibility
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8
Learning objective
B1.1.8—Hydrophobic properties of lipids
New
• Lipids are hydrophobic, sparingly soluble in water, and soluble in non-polar solvents
• Fats, oils, waxes, phospholipids, and steroids are lipid examples
• Lipids are not true polymers because they are not built from repeating identical monomers
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9
Learning objective
B1.1.9—Formation of triglycerides and phospholipids
New
• Condensation forms ester bonds between glycerol and fatty acids
• Triglycerides contain glycerol plus three fatty acids
• Phospholipids contain glycerol, two fatty acids, and an ionized phosphate group
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10
Learning objective
B1.1.10—Fatty acids
New
• Saturated fatty acids have no carbon-carbon double bonds
• Monounsaturated and polyunsaturated fatty acids have one or multiple double bonds
• Double bonds create kinks, lower melting points, and affect membrane and storage properties
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11
Learning objective
B1.1.11—Triglycerides functions
New
• Triglycerides in adipose tissue store concentrated long-term energy
• Insoluble fat stores avoid osmotic effects and can provide insulation, protection, and buoyancy
• Fat oxidation releases more energy and metabolic water than carbohydrate of the same mass
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12
Learning objective
B1.1.12—Phospholipid bilayers
New
• Phospholipids are amphipathic with hydrophilic phosphate heads and hydrophobic tails
• In water they form monolayers or bilayers with tails away from water
• Bilayers are stable barriers and the basic structure of cell membranes
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13
Learning objective
B1.1.13—Non-polar steroids
New
• Steroids are mostly non-polar lipids with four fused carbon rings
• Non-polar steroids pass through the hydrophobic core of phospholipid bilayers
• Oestradiol and testosterone are cholesterol-derived steroid hormone examples
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