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IB Biology HL/Notes/C3.1 Integration of body systems

IB Biology HLC3.1 Integration of body systemsNotes

Link Parts Into Responses

Integration lets interacting parts coordinate an overall biological function. A useful answer traces input, communication, integration, output, and response across molecular, cellular, organ, organism, and ecosystem levels.

Integration lets interacting parts coordinate an overall biological function.
Systems interact across molecular, cellular, organ, organism, and ecosystem levels.
Do not list parts only; explain how the parts produce one coordinated outcome.

Integration means separate parts acting as one coordinated system.

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Build The Body Hierarchy

Cells form tissues, organs, organ systems, and whole organisms. Emergent properties arise when subsystems interact, such as gut peristalsis and absorption: no single smooth-muscle cell digests a meal, but coordinated tissues and organs move and absorb food.

Cells form tissues, organs, organ systems, and whole organisms.
Emergent properties arise when subsystems interact, such as gut peristalsis and absorption.
A cheetah running, a person thinking, or the gut moving food are all system-level outcomes.

Higher levels do things that isolated cells cannot do alone.

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Connect Organs By Signals

Organs are integrated by nervous signals, hormones, and blood transport. Nerves send fast targeted messages, hormones send slower blood-borne messages, and transport links nutrients, gases, wastes, hormones, and energy substrates between organs.

Organs are integrated by nervous signals, hormones, and blood transport.
Transport links nutrients, gases, wastes, hormones, and energy substrates between organs.
Blood is not just a pipe; it is a shared transport route connecting organ functions.

Fast nerves, slower hormones, and material transport integrate organs.

Put the cause-and-response chain in order.

Order
1
Blood is not just a pipe
2
Organs are integrated by nervous signals, hormones, and blood transport.
3
Transport links nutrients, gases, wastes, hormones, and energy substrates between organs.

Put the cause-and-response chain in order.

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Organs are integrated by nervous signals, hormones, and blood transport.
Transport links nutrients, gases, wastes, hormones, and energy substrates between organs.
Blood is not just a pipe

Combine Inputs In The Brain

Practice

The brain integrates sensory input and coordinates complex responses. The cerebral hemispheres combine inputs for perception, learning, and memory, while the cerebellum, hypothalamus, and medulla have distinct roles in movement, endocrine control, and autonomic regulation.

The brain integrates sensory input and coordinates complex responses.
Cerebral hemispheres, cerebellum, hypothalamus, and medulla have distinct roles.
For this syllabus point, focus on combined inputs, learning, and memory rather than neurotransmitter detail.

A student says the brain only receives sensory input. Improve the answer by adding what the brain does with combined inputs.

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Use The Spinal Cord Fast

The spinal cord links brain and peripheral nervous system. It integrates unconscious processes such as reflex arcs, so a withdrawal response can begin before the brain has produced conscious awareness of pain.

The spinal cord links brain and peripheral nervous system.
It integrates unconscious processes such as reflex arcs.
Reflex integration is fast because processing occurs in the spinal cord.

Spot the error: 'A pain reflex must wait for the brain to decide before the muscle contracts.'

Spot Errors

Send Input To The CNS

Sensory neurons carry impulses from receptors to spinal cord and brain. Receptor cells convert stimuli into nerve impulses; some inputs are integrated in spinal reflexes, while others reach the cerebral hemispheres for conscious perception.

Sensory neurons carry impulses from receptors to spinal cord and brain.
Inputs may reach cerebral hemispheres for conscious perception.
Afferent input means information travels toward the CNS.

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Send Output To Muscles

Motor neurons carry impulses from CNS to skeletal muscle effectors. For voluntary movement, cerebral hemispheres coordinate output so muscles are stimulated to contract in a controlled pattern.

Motor neurons carry impulses from CNS to skeletal muscle effectors.
Voluntary muscle contraction is coordinated through cerebral hemispheres.
Efferent output means information travels away from the CNS.

Motor output turns CNS processing into muscle contraction.

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Read A Mixed Nerve

Nerves are bundles of sensory and motor nerve fibres in connective tissue. Mixed nerves carry impulses both to and from the CNS, so one nerve can contain afferent sensory fibres and efferent motor fibres.

Nerves are bundles of sensory and motor nerve fibres in connective tissue.
Mixed nerves carry impulses both to and from the CNS.
A nerve is a bundle; a neuron is a single signalling cell.

Mixed nerves carry two traffic directions in one bundle.

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Trace A Pain Reflex

Pain reflexes are rapid involuntary withdrawal responses. Reflex arcs use receptors, sensory neurons, relay neurons, motor neurons, and skeletal muscle, so the limb can withdraw before conscious decision-making.

Pain reflexes are rapid involuntary withdrawal responses.
Reflex arcs use receptors, sensory neurons, relay neurons, motor neurons, and skeletal muscle.
The relay neuron is in the grey matter of the spinal cord.

A spinal reflex protects first; conscious perception follows.

Put the cause-and-response chain in order.

Order
1
The relay neuron is in the grey matter of the spinal cord.
2
Pain reflexes are rapid involuntary withdrawal responses.
3
Reflex arcs use receptors, sensory neurons, relay neurons, motor neurons, and skeletal muscle.

Put the cause-and-response chain in order.

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Pain reflexes are rapid involuntary withdrawal responses.
Reflex arcs use receptors, sensory neurons, relay neurons, motor neurons, and skeletal muscle.
The relay neuron is in the grey matter of the spinal cord.

Smooth A Movement

Practice

The cerebellum coordinates timing and force of skeletal muscle contractions. It compares intended movement with sensory feedback so balance, posture, and smooth learned movements can be adjusted continuously.

The cerebellum coordinates timing and force of skeletal muscle contractions.
It maintains balance, posture, and smooth learned movements.
Damage often causes poorly coordinated movement rather than paralysis.

Support Cerebellum Role with an inspectable mobile visual.

A student says the cerebellum starts every voluntary movement. Improve the answer.

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A student says the cerebellum starts every voluntary movement. Improve the answer.

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Time Sleep With Melatonin

The pineal gland secretes melatonin according to light-dark cycles. Darkness raises melatonin, while light input from the retina via the hypothalamic suprachiasmatic nucleus suppresses secretion, helping set the sleep-wake rhythm.

The pineal gland secretes melatonin according to light-dark cycles.
Melatonin modulates sleep timing as part of circadian rhythms.
Blue-rich daylight suppresses melatonin and helps entrain the circadian clock.

Spot the error: 'Melatonin is high in bright daylight, so it keeps humans awake.'

Spot Errors

Prepare For Vigorous Activity

Adrenal glands secrete epinephrine during stress or danger. Epinephrine circulates in blood and prepares the body for vigorous activity by increasing heart rate, ventilation, blood flow to skeletal muscles, and respiratory substrate availability.

Adrenal glands secrete epinephrine during stress or danger.
It increases heart rate, ventilation, and respiratory substrate availability.
Blood flow is redirected toward skeletal muscle and away from gut or kidney activity.

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Link Brain To Endocrine Glands

The hypothalamus links nervous inputs to endocrine control. It regulates the pituitary gland, whose hormones influence other endocrine glands including thyroid, gonads, adrenals, and mammary glands.

The hypothalamus links nervous inputs to endocrine control.
Pituitary hormones regulate glands including thyroid, gonads, adrenals, and mammary glands.
You do not need anterior-versus-posterior pituitary mechanisms here; keep the control link clear.

The hypothalamus-pituitary link turns nervous information into endocrine control.

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Adjust Heart Rate

Baroreceptors in the aortic arch and carotid sinuses monitor blood pressure; chemoreceptors monitor CO₂, pH, and O₂. The medulla coordinates autonomic output to the heart, changing sinoatrial node activity, heart rate, and stroke volume.

Baroreceptors monitor blood pressure; chemoreceptors monitor CO₂, pH, and O₂.
The medulla adjusts sinoatrial node activity by sympathetic and parasympathetic nerves.
The response changes cardiac output through heart rate and stroke volume.

Heart-rate control is sensory input plus medulla output to the heart.

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Change Ventilation

Chemoreceptors detect CO₂-driven pH changes in blood and cerebrospinal fluid. The medulla sends signals to the diaphragm and intercostal muscles to change ventilation rate and ventilation volume, removing CO₂ faster when exercise raises respiration.

Chemoreceptors detect CO₂-driven pH changes in blood and cerebrospinal fluid.
The medulla alters diaphragm and intercostal muscle activity to change ventilation rate.
Carbon dioxide lowers pH by forming carbonic acid.

CO₂-driven pH change is the key monitored variable.

Put the cause-and-response chain in order.

Order
1
Carbon dioxide lowers pH by forming carbonic acid.
2
The medulla alters diaphragm and intercostal muscle activity to change ventilation rate.
3
Chemoreceptors detect CO₂-driven pH changes in blood and cerebrospinal fluid.

Put the cause-and-response chain in order.

Choose
Chemoreceptors detect CO₂-driven pH changes in blood and cerebrospinal fluid.
The medulla alters diaphragm and intercostal muscle activity to change ventilation rate.
Carbon dioxide lowers pH by forming carbonic acid.

Coordinate Gut Movement

Practice

The CNS controls voluntary swallowing and egestion. Between those endpoints, the enteric nervous system coordinates involuntary peristalsis in gut smooth muscle so material moves continuously through the alimentary canal.

The CNS controls voluntary swallowing and egestion.
The enteric nervous system coordinates involuntary peristalsis in gut smooth muscle.
Peristalsis uses sequential smooth-muscle contraction to move food along.

Explain why swallowing can be voluntary but most gut movement is not consciously controlled.

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Measure Tropic Responses

Tropisms are directional growth responses in seedlings. Experiments compare shoot or root growth under lateral light or gravity stimuli. A strong investigation records qualitative observations with labelled diagrams and quantitative observations by measuring angle of curvature, then considers reliability, accuracy, and precision.

Tropisms are directional growth responses in seedlings.
Experiments compare shoot or root growth under lateral light or gravity stimuli.
Qualitative observations can use diagrams; quantitative observations can measure angle of curvature.
Repeated trials improve reliability, while careful measuring improves accuracy and precision.

Spot the error: 'A tropism experiment only needs the final direction of growth; measurement quality does not matter.'

Spot Errors

Bend Shoots Toward Light

Shoots show positive phototropism toward lateral light. Auxin redistribution causes greater elongation on the shaded side, so shaded cells elongate more than illuminated cells and the shoot bends toward the light source.

Shoots show positive phototropism toward lateral light.
Auxin redistribution causes greater elongation on the shaded side.
Unequal cell elongation bends the shoot toward the light, improving light capture for photosynthesis.

Put the cause-and-response chain in order.

Order
1
Shoots show positive phototropism toward lateral light.
2
Auxin redistribution causes greater elongation on the shaded side.
3
Unequal cell elongation bends the shoot toward the light, improving light capture for photosynthesis.

Use Plant Hormone Signals

Phytohormones are plant signalling chemicals controlling growth and development. Auxin, cytokinin, and ethylene coordinate responses to stimuli and internal state, so plants can integrate growth direction, root-shoot balance, and fruit ripening without a nervous system.

Phytohormones are plant signalling chemicals controlling growth and development.
Auxin, cytokinin, and ethylene coordinate responses to stimuli and internal state.
Plant integration relies on hormone movement and target-cell responses rather than neurons.

Phytohormones coordinate plant responses across different tissues.

Match each idea to its integration role.

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Polarize Auxin Flow

PIN auxin efflux carriers actively move auxin between plant cells. Auxin can diffuse into cells but becomes trapped after ionization unless efflux carriers export it; asymmetric carrier placement maintains auxin gradients during tropic responses.

PIN auxin efflux carriers actively move auxin between plant cells.
Asymmetric carrier placement maintains auxin gradients during tropic responses.
Coordinated carrier placement on one side of cells drives directional auxin transport.

Polar PIN placement turns local auxin export into a tissue-level gradient.

Put the cause-and-response chain in order.

Order
1
PIN auxin efflux carriers actively move auxin between plant cells.
2
Asymmetric carrier placement maintains auxin gradients during tropic responses.
3
Coordinated carrier placement on one side of cells drives directional auxin transport.

Put the cause-and-response chain in order.

Choose
PIN auxin efflux carriers actively move auxin between plant cells.
Asymmetric carrier placement maintains auxin gradients during tropic responses.
Coordinated carrier placement on one side of cells drives directional auxin transport.

Loosen Walls With Auxin

Auxin activates proton pumping into the apoplast. The lower pH loosens cross-links between cellulose fibres and promotes expansin activity; potassium ion and water entry then increase turgor so acidified cell walls loosen, allowing water uptake, elongation, and bending.

Auxin activates proton pumping into the apoplast.
Acidified cell walls loosen, allowing water uptake, elongation, and bending.
Wall loosening plus turgor pressure explains why one side of a shoot can grow faster.

Auxin promotes elongation by acidifying the cell wall before water-driven expansion.

Put the cause-and-response chain in order.

Order
1
Auxin activates proton pumping into the apoplast.
2
Acidified cell walls loosen, allowing water uptake, elongation, and bending.
3
Wall loosening plus turgor pressure explains why one side of a shoot can grow faster.

Put the cause-and-response chain in order.

Choose
Auxin activates proton pumping into the apoplast.
Acidified cell walls loosen, allowing water uptake, elongation, and bending.
Wall loosening plus turgor pressure explains why one side of a shoot can grow faster.

Balance Roots And Shoots

Practice

Auxin generally promotes root formation; cytokinin promotes shoot formation and division. Shoot tips produce auxin transported to roots, root tips produce cytokinin transported to shoots, and their ratio coordinates root-shoot growth and plant tissue culture outcomes.

Auxin generally promotes root formation; cytokinin promotes shoot formation and division.
Their ratio coordinates root-shoot growth and plant tissue culture outcomes.
Root and shoot tips exchange hormone signals, so each organ affects growth in the other.

A tissue culture has a high auxin:cytokinin ratio in one dish and a high cytokinin:auxin ratio in another. Predict the growth bias in each dish.

Choose

Ripen Fruit Together

Ethylene is a gaseous phytohormone that promotes fruit ripening. Ripening fruit releases more ethylene, creating positive feedback in nearby fruit so ripening is rapid and synchronized.

Ethylene is a gaseous phytohormone that promotes fruit ripening.
Ripening fruit releases more ethylene, creating positive feedback in nearby fruit.
Because ethylene is a gas, one ripening fruit can influence nearby fruit.

Support Ethylene and Fruit Ripening with an inspectable mobile visual.

Spot the error: 'Ethylene is negative feedback because it stops ripening once fruit starts.'

Spot Errors

Spot the error: 'Ethylene is negative feedback because it stops ripening once fruit starts.'

Choose

Core Transfer: Explain Body-System Integration

Exam Practice

Body-system integration lets interacting parts coordinate an overall biological function; systems interact across molecular, cellular, organ, organism, and ecosystem levels. Cells form tissues, organs, organ systems, and whole organisms; emergent properties arise when subsystems interact, such as gut peristalsis and absorption. Organs are integrated by nervous signals, hormones, and blood transport; transport links nutrients, gases, wastes, hormones, and energy substrates between organs. The brain integrates sensory input and coordinates complex responses; cerebral hemispheres, cerebellum, hypothalamus, and medulla have distinct roles. The spinal cord links brain and peripheral nervous system; it integrates unconscious processes such as reflex arcs. Sensory neurons carry impulses from receptors to spinal cord and brain; inputs may reach cerebral hemispheres for conscious perception. Motor neurons carry impulses from CNS to skeletal muscle effectors; voluntary muscle contraction is coordinated through cerebral hemispheres. Nerves are bundles of sensory and motor nerve fibres in connective tissue; mixed nerves carry impulses both to and from the CNS. Pain reflexes are rapid involuntary withdrawal responses; reflex arcs use receptors, sensory neurons, relay neurons, motor neurons, and skeletal muscle. The cerebellum coordinates timing and force of skeletal muscle contractions; it maintains balance, posture, and smooth learned movements. The pineal gland secretes melatonin according to light-dark cycles; melatonin modulates sleep timing as part of circadian rhythms. Adrenal glands secrete epinephrine during stress or danger; it increases heart rate, ventilation, and respiratory substrate availability. The hypothalamus links nervous inputs to endocrine control; pituitary hormones regulate glands including thyroid, gonads, adrenals, and mammary glands. Baroreceptors monitor blood pressure; chemoreceptors monitor CO2, pH, and O2; the medulla adjusts sinoatrial node activity by sympathetic and parasympathetic nerves. Chemoreceptors detect CO2-driven pH changes in blood and cerebrospinal fluid; the medulla alters diaphragm and intercostal muscle activity to change ventilation rate. The CNS controls voluntary swallowing and egestion; the enteric nervous system coordinates involuntary peristalsis in gut smooth muscle.

Integration lets interacting parts coordinate an overall biological function; systems interact across molecular, cellular, organ, organism, and ecosystem levels.
Cells form tissues, organs, organ systems, and whole organisms; emergent properties arise when subsystems interact, such as gut peristalsis and absorption.
Organs are integrated by nervous signals, hormones, and blood transport; transport links nutrients, gases, wastes, hormones, and energy substrates between organs.
The brain integrates sensory input and coordinates complex responses; cerebral hemispheres, cerebellum, hypothalamus, and medulla have distinct roles.
The spinal cord links brain and peripheral nervous system; it integrates unconscious processes such as reflex arcs.
Sensory neurons carry impulses from receptors to spinal cord and brain; inputs may reach cerebral hemispheres for conscious perception.
Motor neurons carry impulses from CNS to skeletal muscle effectors; voluntary muscle contraction is coordinated through cerebral hemispheres.
Nerves are bundles of sensory and motor nerve fibres in connective tissue; mixed nerves carry impulses both to and from the CNS.
Pain reflexes are rapid involuntary withdrawal responses; reflex arcs use receptors, sensory neurons, relay neurons, motor neurons, and skeletal muscle.
The cerebellum coordinates timing and force of skeletal muscle contractions; it maintains balance, posture, and smooth learned movements.
The pineal gland secretes melatonin according to light-dark cycles; melatonin modulates sleep timing as part of circadian rhythms.
Adrenal glands secrete epinephrine during stress or danger; it increases heart rate, ventilation, and respiratory substrate availability.
The hypothalamus links nervous inputs to endocrine control; pituitary hormones regulate glands including thyroid, gonads, adrenals, and mammary glands.
Baroreceptors monitor blood pressure; chemoreceptors monitor CO2, pH, and O2; the medulla adjusts sinoatrial node activity by sympathetic and parasympathetic nerves.
Chemoreceptors detect CO2-driven pH changes in blood and cerebrospinal fluid; the medulla alters diaphragm and intercostal muscle activity to change ventilation rate.
The CNS controls voluntary swallowing and egestion; the enteric nervous system coordinates involuntary peristalsis in gut smooth muscle.

Put the cluster answer frame in order.

Order
1
The spinal cord links brain and peripheral nervous system
2
Cells form tissues, organs, organ systems, and whole organisms
3
Motor neurons carry impulses from CNS to skeletal muscle effectors
4
The brain integrates sensory input and coordinates complex responses
5
Sensory neurons carry impulses from receptors to spinal cord and brain
6
Organs are integrated by nervous signals, hormones, and blood transport
7
Nerves are bundles of sensory and motor nerve fibres in connective tissue
8
Integration lets interacting parts coordinate an overall biological function

Use this for questions that combine nervous, endocrine, transport, and feedback control in body-system integration.

Integration lets interacting parts coordinate an overall biological function; systems interact across molecular, cellular, organ, organism, and ecosystem levels.
Cells form tissues, organs, organ systems, and whole organisms; emergent properties arise when subsystems interact, such as gut peristalsis and absorption.
Organs are integrated by nervous signals, hormones, and blood transport; transport links nutrients, gases, wastes, hormones, and energy substrates between organs.
The brain integrates sensory input and coordinates complex responses; cerebral hemispheres, cerebellum, hypothalamus, and medulla have distinct roles.
The spinal cord links brain and peripheral nervous system; it integrates unconscious processes such as reflex arcs.
Sensory neurons carry impulses from receptors to spinal cord and brain; inputs may reach cerebral hemispheres for conscious perception.
Motor neurons carry impulses from CNS to skeletal muscle effectors; voluntary muscle contraction is coordinated through cerebral hemispheres.
Nerves are bundles of sensory and motor nerve fibres in connective tissue; mixed nerves carry impulses both to and from the CNS.
Pain reflexes are rapid involuntary withdrawal responses; reflex arcs use receptors, sensory neurons, relay neurons, motor neurons, and skeletal muscle.
The cerebellum coordinates timing and force of skeletal muscle contractions; it maintains balance, posture, and smooth learned movements.
The pineal gland secretes melatonin according to light-dark cycles; melatonin modulates sleep timing as part of circadian rhythms.
Adrenal glands secrete epinephrine during stress or danger; it increases heart rate, ventilation, and respiratory substrate availability.
The hypothalamus links nervous inputs to endocrine control; pituitary hormones regulate glands including thyroid, gonads, adrenals, and mammary glands.
Baroreceptors monitor blood pressure; chemoreceptors monitor CO2, pH, and O2; the medulla adjusts sinoatrial node activity by sympathetic and parasympathetic nerves.
Chemoreceptors detect CO2-driven pH changes in blood and cerebrospinal fluid; the medulla alters diaphragm and intercostal muscle activity to change ventilation rate.
The CNS controls voluntary swallowing and egestion; the enteric nervous system coordinates involuntary peristalsis in gut smooth muscle.

Use this for questions that combine nervous, endocrine, transport, and feedback control in body-system integration.

Common loss: naming the organ, hormone, or plant response without the mechanism that links cause to effect.

HL Transfer: Explain Plant Signalling Integration

Exam Practice

Plant signalling integrates directional growth, phytohormones, and responses to stimuli. Tropisms are directional growth responses in seedlings; experiments compare shoot or root growth under lateral light or gravity stimuli. Shoots show positive phototropism toward lateral light; auxin redistribution causes greater elongation on the shaded side. Phytohormones are plant signalling chemicals controlling growth and development; auxin, cytokinin, and ethylene coordinate responses to stimuli and internal state. PIN auxin efflux carriers actively move auxin between plant cells; asymmetric carrier placement maintains auxin gradients during tropic responses. Auxin activates proton pumping into the apoplast; acidified cell walls loosen, allowing water uptake, elongation, and bending. Auxin generally promotes root formation; cytokinin promotes shoot formation and division; their ratio coordinates root-shoot growth and plant tissue culture outcomes. Ethylene is a gaseous phytohormone that promotes fruit ripening; ripening fruit releases more ethylene, creating positive feedback in nearby fruit.

Tropisms are directional growth responses in seedlings; experiments compare shoot or root growth under lateral light or gravity stimuli.
Shoots show positive phototropism toward lateral light; auxin redistribution causes greater elongation on the shaded side.
Phytohormones are plant signalling chemicals controlling growth and development; auxin, cytokinin, and ethylene coordinate responses to stimuli and internal state.
PIN auxin efflux carriers actively move auxin between plant cells; asymmetric carrier placement maintains auxin gradients during tropic responses.
Auxin activates proton pumping into the apoplast; acidified cell walls loosen, allowing water uptake, elongation, and bending.
Auxin generally promotes root formation; cytokinin promotes shoot formation and division; their ratio coordinates root-shoot growth and plant tissue culture outcomes.
Ethylene is a gaseous phytohormone that promotes fruit ripening; ripening fruit releases more ethylene, creating positive feedback in nearby fruit.

Put the cluster answer frame in order.

Order
1
Auxin generally promotes root formation
2
Auxin activates proton pumping into the apoplast
3
Tropisms are directional growth responses in seedlings
4
Shoots show positive phototropism toward lateral light
5
Ethylene is a gaseous phytohormone that promotes fruit ripening
6
PIN auxin efflux carriers actively move auxin between plant cells
7
Phytohormones are plant signalling chemicals controlling growth and development

Use this for HL questions on tropisms, auxin transport/action, cytokinin balance, and ethylene ripening.

Tropisms are directional growth responses in seedlings; experiments compare shoot or root growth under lateral light or gravity stimuli.
Shoots show positive phototropism toward lateral light; auxin redistribution causes greater elongation on the shaded side.
Phytohormones are plant signalling chemicals controlling growth and development; auxin, cytokinin, and ethylene coordinate responses to stimuli and internal state.
PIN auxin efflux carriers actively move auxin between plant cells; asymmetric carrier placement maintains auxin gradients during tropic responses.
Auxin activates proton pumping into the apoplast; acidified cell walls loosen, allowing water uptake, elongation, and bending.
Auxin generally promotes root formation; cytokinin promotes shoot formation and division; their ratio coordinates root-shoot growth and plant tissue culture outcomes.
Ethylene is a gaseous phytohormone that promotes fruit ripening; ripening fruit releases more ethylene, creating positive feedback in nearby fruit.

Use this for HL questions on tropisms, auxin transport/action, cytokinin balance, and ethylene ripening.

Common loss: naming the organ, hormone, or plant response without the mechanism that links cause to effect.